膽囊切除術後症候群
膽囊切除術後症候群(Postcholecystectomy syndrome)是描述在膽囊切除術之後出現的一系列腹部症狀。
膽囊切除術後症候群 | |
---|---|
分類和外部資源 | |
醫學專科 | 胃腸學 |
ICD-11 | DC14.1 |
ICD-9-CM | 576.0 |
大約5-40%的膽囊切除術患者會出現此類術後症候群[1],此類症狀可能暫時出現,可能持續一陣子,也有一些人伴隨終身[2][3]。有約10%的術後患者出現慢性症狀。
術後症候群的腹痛症狀可能來自於歐蒂氏括約肌功能不全或術後沾黏[4]。一項近期研究顯示術後症候群可能肇因於膽道微結石[5]。約50%的病例是源自於膽道系統,例如殘餘結石、膽道損傷、膽道運動不良,以及膽道囊腫。非膽道源性術後症候群則可能肇因於腸胃道功能性失調,例如消化不良[6]。
慢性膽囊切除術後症候群屬於一種膽酸性腹瀉[3],此類患者可以使用膽酸結合劑進行治療,如可林斯提拉明酯(cholestyramine)[3]、考來替泊(colestipol)[2],或colesevelam[7]等藥物都能夠治療且安全[8]。
症狀
相關症狀包含[9]:
診斷
- 腹部超聲波
- 常規性血液檢查及生化檢驗
- 靜脈膽管造影術
- 胃十二指腸內視鏡
- 經內視鏡逆行性膽胰管攝影術(ERCP)
- 經內視鏡逆行性膽胰管攝影術(ERCP)取得膽泥分析
- SeHCAT或其他與膽酸性腹瀉相關檢驗
參考文獻
- ^ Postcholecystectomy syndrome. WebMD. [2009-03-07]. (原始內容存檔於2007-07-02).
- ^ 2.0 2.1 Danley T, St Anna L. Clinical inquiry. Postcholecystectomy diarrhea: what relieves it?. The Journal of Family Practice. October 2011, 60 (10): 632c–d [2019-04-11]. PMID 21977493. (原始內容存檔於2019-12-13).
- ^ 3.0 3.1 3.2 Sciarretta G, Furno A, Mazzoni M, Malaguti P. Post-cholecystectomy diarrhea: evidence of bile acid malabsorption assessed by SeHCAT test. The American Journal of Gastroenterology. December 1992, 87 (12): 1852–4. PMID 1449156.
- ^ Hyvärinen H, Sipponen P, Silvennoinen E. Intestinal adhesions: an overlooked cause of the postcholecystectomy syndrome. Hepatogastroenterology. December 1990, 37 (Suppl 2): 58–61. PMID 2083937.
- ^ Okoro N, Patel A, Goldstein M, Narahari N, Cai Q. Ursodeoxycholic acid treatment for patients with postcholecystectomy pain and bile microlithiasis. Gastrointestinal Endoscopy. July 2008, 68 (1): 69–74. PMID 18577477. doi:10.1016/j.gie.2007.09.046.
- ^ Post-cholecystectomy symptoms were caused by persistence of a functional gastrointestinal disorder. [2019-04-11]. (原始內容存檔於2019-12-17).
- ^ Odunsi-Shiyanbade ST, Camilleri M, McKinzie S, et al. Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function. Clinical Gastroenterology and Hepatology. February 2010, 8 (2): 159–65. PMC 2822105 . PMID 19879973. doi:10.1016/j.cgh.2009.10.020.
- ^ Mottacki N, Simrén M, Bajor A. Review article: bile acid diarrhoea - pathogenesis, diagnosis and management. Aliment. Pharmacol. Ther. 2016, 43: 884–898. PMID 26913381. doi:10.1111/apt.13570.
- ^ nhs.uk, Complications of a gallbladder removal (頁面存檔備份,存於互聯網檔案館)
- ^ Lamberts MP, Lugtenberg M, Rovers MM, Roukema AJ, Drenth JP, Westert GP, van Laarhoven CJ. Persistent and de novo symptoms after cholecystectomy: a systematic review of cholecystectomy effectiveness. Surg Endosc. 2013, 27 (3): 709–18. PMID 23052498. doi:10.1007/s00464-012-2516-9.