1-氨基-1-羧基茚滿-5-磷酸
化合物
1-氨基-1-羧基茚滿-5-磷酸（APICA）是一種有機化合物，化學式為C10H12NO5P。它是一種藥物，可用於神經科學研究。它是II組代謝型穀氨酸受體 (mGluR2/3) 的選擇性拮抗劑。[1][2][3]它可以3-溴苯甲醛和亞磷酸二乙酯為原料經多步反應製得。[2]
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| 臨床資料 | |
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| 識別資訊 | |
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| CAS號 | 170847-18-4  |
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| CompTox Dashboard (EPA) | |
| 化學資訊 | |
| 化學式 | C10H12NO5P |
| 摩爾質量 | 257.18 g·mol−1 |
| 3D模型（JSmol） | |
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參考文獻
- ^ Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT. Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists.. Bioorganic & Medicinal Chemistry Letters. May 1997, 7 (9): 1195–1198. doi:10.1016/S0960-894X(97)00177-7
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- ^ 2.0 2.1 Ma D, Tian H, Zou G. Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors. The Journal of Organic Chemistry. January 1999, 64 (1): 120–125. PMID 11674092. doi:10.1021/jo981297a.
- ^ Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW. Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. The Journal of Pharmacology and Experimental Therapeutics. January 2002, 300 (1): 162–71. PMID 11752112. doi:10.1124/jpet.300.1.162.
