1-羥基菲
化合物
1-羥基菲（英語：1-Hydroxyphenanthrene）或叫1-羥菲，是一種菲酚和菲的人體代謝物，可以在暴露於多環芳香烴的人的尿液中檢測到。[1]
| 1-羥基菲 | |
|---|---|
| |
| IUPAC名 Phenanthren-1-ol 菲-1-酚 | |
| 別名 | 1-菲酚 1-菲醇 1-羥基菲 1-羥菲 |
| 識別 | |
| CAS編號 | 2433-56-9 
|
| PubChem | 98490 |
| ChemSpider | 88945 |
| SMILES |
|
| 性質 | |
| 化學式 | C14H10O |
| 摩爾質量 | 194.23 g·mol⁻¹ |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
它還可以用作海洋魚膽汁中多環芳香烴污染的標記物。[2]
在菲生物降解的情況下，模型真菌雅致小克銀漢霉產生1-羥基菲（菲1-O-β-葡萄糖）的糖苷共軛物。[3]
與吸煙的關係
對於2-、3-和4-羥基菲和1-羥基芘，發現了與每天吸食的香煙有關的高度顯着差異和劑量反應關係，但對於1-羥基菲則沒有。[4]
參考資料
- ^ PAH metabolites (1-hydroxyphenanthrene, 4-hydroxyphenanthrene, 9-hydroxyphenanthrene, 1-hydroxypyrene). The MAK Collection for Occupational Health and Safety, Biomonitoring Methods, Vol. 6 (article （頁面存檔備份，存於互聯網檔案館）)
- ^ PAH Metabolites in Bile Fluids of Dab (Limanda limanda) and Flounder (Platichthys flesus): Spatial Distribution and Seasonal Changes. Ulrike Kammann, Environmental Science and Pollution Research - International, March 2007, Volume 14, Issue 2, pages 102-108, doi:10.1065/espr2006.05.308
- ^ Cerniglia, C. E.; Campbell, W. L.; Freeman, J. P.; Evans, F. E. Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans. Applied and Environmental Microbiology. 1989, 55 (9): 2275–2279. PMC 203068
. PMID 2802607. doi:10.1128/AEM.55.9.2275-2279.1989.
- ^ Urinary monohydroxylated phenanthrenes and hydroxypyrene – the effects of smoking habits and changes induced by smoking on monooxygenase-mediated metabolism. Heudorf U and Angerer J, International Archives of Occupational and Environmental Health, April 2001, Volume 74, Issue 3, pages 177-183, doi:10.1007/s004200000215
