CGP-7930
化合物
CGP-7930(化學名: 2,6-二叔丁基-4-(3-羥基-2,2-二甲基丙基)-苯酚,2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol)是一種有機化合物,是GABAB受體的正向別構調節劑,其作用效果和其同系物BSPP類似[1][2][3][4]。
識別資訊 | |
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CAS號 | 57717-80-3 |
PubChem CID | |
IUPHAR/BPS | |
ChemSpider | |
CompTox Dashboard (EPA) | |
化學資訊 | |
化學式 | C19H32O2 |
摩爾質量 | 292.46 g·mol−1 |
3D模型(JSmol) | |
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參考文獻
- ^ Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, et al. Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501. Molecular Pharmacology. November 2001, 60 (5): 963–71. PMID 11641424.
- ^ Binet V, Brajon C, Le Corre L, Acher F, Pin JP, Prézeau L. The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor. The Journal of Biological Chemistry. July 2004, 279 (28): 29085–91. PMID 15126507. doi:10.1074/jbc.M400930200 .
- ^ Chen Y, Menendez-Roche N, Sher E. Differential modulation by the GABAB receptor allosteric potentiator 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of synaptic transmission in the rat hippocampal CA1 area. The Journal of Pharmacology and Experimental Therapeutics. June 2006, 317 (3): 1170–7. PMID 16507713. doi:10.1124/jpet.105.099176.
- ^ Adams CL, Lawrence AJ. CGP7930: a positive allosteric modulator of the GABAB receptor. CNS Drug Reviews: 308–16. PMC 6494120 . PMID 17894647. doi:10.1111/j.1527-3458.2007.00021.x.