埃巴單抗

化合物

埃巴單抗(INN:Edobacomab),開發代號為E5,是一種小鼠單株抗體,被研究作為革蘭氏陰性細菌感染引起的敗血症的可能治療方法。

埃巴單抗
單株抗體
種類完整抗體
目標內毒素
臨床資料
給藥途徑靜脈注射
ATC碼
  • 未分配
識別資訊
CAS號141410-98-2  checkY
ChemSpider
UNII

延伸閱讀

  • Greenman RL, Schein RM, Martin MA, Wenzel RP, MacIntyre NR, Emmanuel G, et al. A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group. JAMA. August 1991, 266 (8): 1097–102. PMID 1865542. doi:10.1001/jama.266.8.1097. 
  • Bone RC, Balk RA, Fein AM, Perl TM, Wenzel RP, Reines HD, et al. A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group. Critical Care Medicine. June 1995, 23 (6): 994–1006. PMID 7774238. doi:10.1097/00003246-199506000-00003. 
  • Angus DC, Birmingham MC, Balk RA, Scannon PJ, Collins D, Kruse JA, et al. E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators. JAMA. April 2000, 283 (13): 1723–30. PMID 10755499. doi:10.1001/jama.283.13.1723 .