膽囊收縮素

膽囊收縮素
識別號
別名	CCK；, cholecystokinin
外部ID	OMIM：118440 MGI：88297 HomoloGene：583 GeneCards：CCK
基因位置（人類）
染色體	3號染色體
終止	42,266,185 bp
基因位置（小鼠）
染色體	小鼠9號染色體
終止	121,324,760 bp
RNA表達模式
	查閱更多表達數據
基因本體
分子功能	• hormone activity; • 血漿蛋白結合; • neuropeptide hormone activity; • peptide hormone receptor binding;
細胞組分	• 細胞本體; • 細胞外區域; • 末梢神經; • soma; • 樹突; • 軸丘; • axon initial segment; • 細胞外空間; • 軸突;
生物學過程	• regulation of sensory perception of pain; • eating behavior; • behavioral fear response; • negative regulation of appetite; • protein kinase C-activating G protein-coupled receptor signaling pathway; • positive regulation of mitochondrial depolarization; • positive regulation of glutamate secretion; • positive regulation of cell population proliferation; • positive regulation of protein oligomerization; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of apoptotic process; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • 信號轉導; • release of cytochrome c from mitochondria; • 細胞凋亡; • neuron migration; • axonogenesis; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • 記憶; • visual learning; • negative regulation of eating behavior; • positive regulation of sensory perception of pain; • negative regulation of behavioral fear response; • positive regulation of behavioral fear response; • 消化作用;
	Sources:Amigo / QuickGO
直系同源
	885
	12424
	ENSG00000187094
	ENSMUSG00000032532
	P06307
	P09240
	NM_000729; NM_001174138
	NM_031161; NM_001284508
	NP_000720; NP_001167609
	NP_001271437; NP_112438
	維基數據
檢視/編輯人類	檢視/編輯小鼠

膽囊收縮素（英語：cholecystokinin，簡稱CCK或CCK-PZ）是一種腦腸肽，主要功能是促進脂肪和蛋白質的消化。其名稱源自希臘語，包含chole（膽汁）、cysto（囊狀）和kinin（移動）三個部分，整體意為「移動膽汁之囊」。它不僅在消化系統中廣泛存在，還在中樞及外周神經系統中發揮作用^[5]。

膽囊收縮素在此之前名為促胰酶素（pancreozymin），是由小腸的黏膜上皮細胞當中的I細胞所合成，並由十二指腸分泌。當膽囊收縮素被分泌出來後，會刺激胰臟和膽囊分別釋放消化酶和膽汁，以幫助消化過程。

除了在消化過程中發揮作用，膽囊收縮素還是一種食慾抑制劑。當膽囊收縮素在體內水平升高時，可以抑制食慾，幫助控制食物的攝入量。最近的證據暗示，膽囊收縮素在促進鴉片類藥物的藥物容許量，如嗎啡和海洛英，扮演着重要角色，並且在經歷鴉片類藥物停藥後的疼痛過敏經歷有着部份的關聯性^[6]^[7]。

膽囊收縮素基因最早在狗（Canis lupus familiaris）的胃腸道中被發現^[8]，隨後在人類（Homo sapiens）、小鼠（Mus musculus）、虹鱒（Oncorhynchus mykiss）、大西洋鮭（Salmo salar）和團頭魴（Megalobrama amblycephala）等多個物種中也有發現^[5]。研究表明，不同動物中的膽囊收縮素存在兩種甚至三種不同的亞型，並且它們的功能存在差異^[5]。例如，在虹鱒中存在CCK-L、CCK-N和CCK-T三種膽囊收縮素亞型，其中CCK-L亞型作為飽腹因子調節攝食，而CCK-N亞型則無顯著作用^[9]。在紅鯛（Pagrus major）中發現CCK基因存在CCK1和CCK2亞型，其中CCK1亞型在消化過程中發揮重要作用，CCK2亞型則通過向腦發送信號調節食物攝入和控制飽腹感^[10]。而在白鯛（Diplodus sargus）中，CCK1基因的表達水平不受攝食影響，CCK2基因則參與消化過程的負反饋調節^[11]。

膽囊收縮素基因通過與膽囊收縮素受體基因（Cholecystokinin receptor，簡稱CCKR）相結合，調節動物的攝食、消化等生理過程^[12]。在多數動物中，CCKR基因存在CCK1R和CCK2R兩種亞型^[13]。研究顯示，CCK與CCK1R基因結合主要影響消化系統，而CCK與CCK2R基因結合則主要影響中樞神經系統，二者共同參與攝食活動的調節過程^[14]。

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000187094 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000032532 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^5.0 ^5.1 ^5.2 禁食和复投喂对大口黑鲈胆囊收缩素及其受体基因表达的影响. 水生生物學報. 2023-08-15, 47 (8): 1220–1227. doi:10.7541/2023.2022.0175.
^ Kissin I, Bright CA, Bradley EL. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. Anesth. Analg. 2000, 91 (1): 110–6 [2013-12-02]. PMID 10866896. doi:10.1097/00000539-200007000-00021. （原始內容存檔於2007-12-06）.
^ Fukazawa Y, Maeda T, Kiguchi N, Tohya K, Kimura M, Kishioka S. Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats. J. Pharmacol. Sci. 2007, 104 (2): 159–66. PMID 17558184. doi:10.1254/jphs.FP0070475.
^ Ivy, A. C.; Oldberg, E. Contraction and Evacuation of Gall-Bladder Caused by Highly Purified "Secretin" Preparation.. Experimental Biology and Medicine. 1927-11-01, 25 (2): 113–115. doi:10.3181/00379727-25-3724.
^ Jensen, H; Rourke, IJ; Møller, M; Jønson, L; Johnsen, AH. Identification and distribution of CCK-related peptides and mRNAs in the rainbow trout, Oncorhynchus mykiss.. Biochimica et biophysica acta. 2001-01-26, 1517 (2): 190–201. PMID 11342099. doi:10.1016/s0167-4781(00)00263-3.
^ Huong, Tran Thi Mai; Murashita, Koji; Senzui, Ayaka; Matsumoto, Toshiro; Fukada, Haruhisa. Cholecystokinin 1 and 2 in red seabream Pagrus major: molecular cloning, response to feeding, and a potential indicator of dietary protein source quality. Fisheries Science. 2020-09, 86 (5): 835–849. doi:10.1007/s12562-020-01443-z.
^ Micale, V; Campo, S; D'Ascola, A; Guerrera, MC; Levanti, MB; Germanà, A; Muglia, U. Cholecystokinin in white sea bream: molecular cloning, regional expression, and immunohistochemical localization in the gut after feeding and fasting.. PloS one. 2012, 7 (12): e52428. PMID 23285038. doi:10.1371/journal.pone.0052428.
^ Yu, N; Smagghe, G. CCK(-like) and receptors: structure and phylogeny in a comparative perspective.. General and comparative endocrinology. 2014-12-01, 209: 74–81. PMID 24842717. doi:10.1016/j.ygcen.2014.05.003.
^ Dufresne, M; Seva, C; Fourmy, D. Cholecystokinin and gastrin receptors.. Physiological reviews. 2006-07, 86 (3): 805–47. PMID 16816139. doi:10.1152/physrev.00014.2005.
^ Balaskó, M.; Rostás, I.; Füredi, N.; Mikó, A.; Tenk, J.; Cséplő, P.; Koncsecskó-Gáspár, M.; Soós, S.; Székely, M.; Pétervári, E. Age and nutritional state influence the effects of cholecystokinin on energy balance. Experimental Gerontology. 2013-11, 48 (11): 1180–1188. doi:10.1016/j.exger.2013.07.006.

外部連結

醫學主題詞表（MeSH）：Cholecystokinin

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000187094 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000032532 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[2022.0175-5] 5.0 ^5.1 ^5.2 禁食和复投喂对大口黑鲈胆囊收缩素及其受体基因表达的影响. 水生生物學報. 2023-08-15, 47 (8): 1220–1227. doi:10.7541/2023.2022.0175.

[pmid10866896-6] Kissin I, Bright CA, Bradley EL. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. Anesth. Analg. 2000, 91 (1): 110–6 [2013-12-02]. PMID 10866896. doi:10.1097/00000539-200007000-00021. （原始內容存檔於2007-12-06）.

[pmid17558184-7] Fukazawa Y, Maeda T, Kiguchi N, Tohya K, Kimura M, Kishioka S. Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats. J. Pharmacol. Sci. 2007, 104 (2): 159–66. PMID 17558184. doi:10.1254/jphs.FP0070475.

[8] Ivy, A. C.; Oldberg, E. Contraction and Evacuation of Gall-Bladder Caused by Highly Purified "Secretin" Preparation.. Experimental Biology and Medicine. 1927-11-01, 25 (2): 113–115. doi:10.3181/00379727-25-3724.

[9] Jensen, H; Rourke, IJ; Møller, M; Jønson, L; Johnsen, AH. Identification and distribution of CCK-related peptides and mRNAs in the rainbow trout, Oncorhynchus mykiss.. Biochimica et biophysica acta. 2001-01-26, 1517 (2): 190–201. PMID 11342099. doi:10.1016/s0167-4781(00)00263-3.

[10] Huong, Tran Thi Mai; Murashita, Koji; Senzui, Ayaka; Matsumoto, Toshiro; Fukada, Haruhisa. Cholecystokinin 1 and 2 in red seabream Pagrus major: molecular cloning, response to feeding, and a potential indicator of dietary protein source quality. Fisheries Science. 2020-09, 86 (5): 835–849. doi:10.1007/s12562-020-01443-z.

[11] Micale, V; Campo, S; D'Ascola, A; Guerrera, MC; Levanti, MB; Germanà, A; Muglia, U. Cholecystokinin in white sea bream: molecular cloning, regional expression, and immunohistochemical localization in the gut after feeding and fasting.. PloS one. 2012, 7 (12): e52428. PMID 23285038. doi:10.1371/journal.pone.0052428.

[12] Yu, N; Smagghe, G. CCK(-like) and receptors: structure and phylogeny in a comparative perspective.. General and comparative endocrinology. 2014-12-01, 209: 74–81. PMID 24842717. doi:10.1016/j.ygcen.2014.05.003.

[13] Dufresne, M; Seva, C; Fourmy, D. Cholecystokinin and gastrin receptors.. Physiological reviews. 2006-07, 86 (3): 805–47. PMID 16816139. doi:10.1152/physrev.00014.2005.

[14] Balaskó, M.; Rostás, I.; Füredi, N.; Mikó, A.; Tenk, J.; Cséplő, P.; Koncsecskó-Gáspár, M.; Soós, S.; Székely, M.; Pétervári, E. Age and nutritional state influence the effects of cholecystokinin on energy balance. Experimental Gerontology. 2013-11, 48 (11): 1180–1188. doi:10.1016/j.exger.2013.07.006.

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