7-甲基辛酸

7-甲基辛酸
英文名	7-Methyloctanoic acid
識別
CAS號	693-19-6
SMILES	CC(C)CCCCCC(O)=O;
性質
化學式	C9H18O2
摩爾質量	158.24 g·mol⁻¹
密度	0.919±0.06 g·cm−3
熔點	3—5 °C（276—278 K）
沸點	248 °C（521 K）（765 Torr）
溶解性（水）	0.11 g
pKa	4.78±0.10
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

7-甲基辛酸是一種有機化合物，化學式為C₉H₁₈O₂，它是異壬酸（德語：Isononansäure）的同分異構體之一。^[4]

製備

7-甲基辛酸可由7-甲基辛醇和吡啶重鉻酸鹽（或三氧化鉻^[2]）的氧化反應製得。^[5]6-溴己酸鈉和異丙基氯化鎂反應，酸化後加水可以析出7-甲基辛酸。^[6]

7-甲基辛酸甲酯在鹼性條件下水解^[7]，或7-甲基-7-辛烯酸在鈀碳的催化下由氫氣還原，也能得到產物。^[8]

性質

7-甲基辛酸和光氣加熱反應，得到7-甲基辛酰氯；^[9]在酸性催化劑的催化下，也能和醇反應生成酯。^[10]^[11]

參考文獻

^ ^1.0 ^1.1 ^1.2 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ((C) 1994-2020 ACD/Labs). Retrieved from SciFinder. [2020-07-25].
^ ^2.0 ^2.1 Klimentová, Jana; Kosák, Petr; Vávrová, Kateřina; Holas, Tomáš; Hrabálek, Alexandr. Influence of terminal branching on the transdermal permeation-enhancing activity in fatty alcohols and acids. Bioorganic & Medicinal Chemistry. 2006, 14 (23): 7681–7687. ISSN 0968-0896. doi:10.1016/j.bmc.2006.08.013.
^ Levene, P. A.; Allen, C. H. The oxidation of branched-chain fatty acids. I. The action of hydrogen peroxide on the homologs of isobutyric acid. Journal of Biological Chemistry, 1916. 27: 433-462. ISSN: 0021-9258.
^ Isononansäure Nr.276. (PDF) (PDF). Berufsgenossenschaft Rohstoffe und chemische Industrie (BG RCI). 2010 [2020-07-25]. （原始內容存檔 (PDF)於2016-03-24）.
^ Cooper, Matthew; Blaskovich, Mark; Alejandra, Gallardo-Goday; Hansford, Karl; Elliott, Alysha. Peptide antibiotics. 2019. WO 2019084628 A1.
^ Thiel, Verena; Kunze, Brigitte; Verma, Pankaj; Wagner-Döbler, Irene; Schulz, Stefan. New Structural Variants of Homoserine Lactones in Bacteria. ChemBioChem. 2009, 10 (11): 1861–1868. ISSN 1439-4227. doi:10.1002/cbic.200900126.
^ Riclea, Ramona; Aigle, Bertrand; Leblond, Pierre; Schoenian, Ilka; Spiteller, Dieter; Dickschat, Jeroen S. Volatile Lactones from Streptomycetes Arise via the Antimycin Biosynthetic Pathway. ChemBioChem. 2012, 13 (11): 1635–1644. ISSN 1439-4227. doi:10.1002/cbic.201200260.
^ Cui, A-Long; Hu, Xin-Xin; Gao, Yan; Jin, Jie; Yi, Hong; Wang, Xiu-Kun; Nie, Tong-Ying; Chen, Yang; He, Qi-Yang; Guo, Hui-Fang; Jiang, Jian-Dong; You, Xue-Fu; Li, Zhuo-Rong. Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics. Journal of Medicinal Chemistry. 2018, 61 (5): 1845–1857. ISSN 0022-2623. doi:10.1021/acs.jmedchem.7b01367.
^ Lan, Xingfen; Qiu, Xuenan; Peng, Jiuhe. Process for preparation of acyl chloride compounds. 2016. CN 105585478 A.
^ Springer, Helmut; Merscher, Klaus-Dieter; Heumueller, Rudolf; Schimmer, Klaus; Strutz, Heinz. Process for the production of glycol-carboxylate ester plasticizers with the azeotropic distillative removal of process water. 2001. DE 19940991 A1.
^ Mun, Dasom; Vo, Anh Thi Hoang; Kim, Bora; Shul, Yong-Gun; Cho, Jin Ku. Solventless esterification of fatty acids with trimethylolpropane using sulfonated amorphous carbons derived from wood powder. Catalysis Communications. 2017, 96: 32–36. ISSN 1566-7367. doi:10.1016/j.catcom.2017.03.015.

[ACD-1] 1.0 ^1.1 ^1.2 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ((C) 1994-2020 ACD/Labs). Retrieved from SciFinder. [2020-07-25].

[#1-2] 2.0 ^2.1 Klimentová, Jana; Kosák, Petr; Vávrová, Kateřina; Holas, Tomáš; Hrabálek, Alexandr. Influence of terminal branching on the transdermal permeation-enhancing activity in fatty alcohols and acids. Bioorganic & Medicinal Chemistry. 2006, 14 (23): 7681–7687. ISSN 0968-0896. doi:10.1016/j.bmc.2006.08.013.

[3] Levene, P. A.; Allen, C. H. The oxidation of branched-chain fatty acids. I. The action of hydrogen peroxide on the homologs of isobutyric acid. Journal of Biological Chemistry, 1916. 27: 433-462. ISSN: 0021-9258.

[4] Isononansäure Nr.276. (PDF) (PDF). Berufsgenossenschaft Rohstoffe und chemische Industrie (BG RCI). 2010 [2020-07-25]. （原始內容存檔 (PDF)於2016-03-24）.

[5] Cooper, Matthew; Blaskovich, Mark; Alejandra, Gallardo-Goday; Hansford, Karl; Elliott, Alysha. Peptide antibiotics. 2019. WO 2019084628 A1.

[6] Thiel, Verena; Kunze, Brigitte; Verma, Pankaj; Wagner-Döbler, Irene; Schulz, Stefan. New Structural Variants of Homoserine Lactones in Bacteria. ChemBioChem. 2009, 10 (11): 1861–1868. ISSN 1439-4227. doi:10.1002/cbic.200900126.

[7] Riclea, Ramona; Aigle, Bertrand; Leblond, Pierre; Schoenian, Ilka; Spiteller, Dieter; Dickschat, Jeroen S. Volatile Lactones from Streptomycetes Arise via the Antimycin Biosynthetic Pathway. ChemBioChem. 2012, 13 (11): 1635–1644. ISSN 1439-4227. doi:10.1002/cbic.201200260.

[8] Cui, A-Long; Hu, Xin-Xin; Gao, Yan; Jin, Jie; Yi, Hong; Wang, Xiu-Kun; Nie, Tong-Ying; Chen, Yang; He, Qi-Yang; Guo, Hui-Fang; Jiang, Jian-Dong; You, Xue-Fu; Li, Zhuo-Rong. Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics. Journal of Medicinal Chemistry. 2018, 61 (5): 1845–1857. ISSN 0022-2623. doi:10.1021/acs.jmedchem.7b01367.

[9] Lan, Xingfen; Qiu, Xuenan; Peng, Jiuhe. Process for preparation of acyl chloride compounds. 2016. CN 105585478 A.

[10] Springer, Helmut; Merscher, Klaus-Dieter; Heumueller, Rudolf; Schimmer, Klaus; Strutz, Heinz. Process for the production of glycol-carboxylate ester plasticizers with the azeotropic distillative removal of process water. 2001. DE 19940991 A1.

[11] Mun, Dasom; Vo, Anh Thi Hoang; Kim, Bora; Shul, Yong-Gun; Cho, Jin Ku. Solventless esterification of fatty acids with trimethylolpropane using sulfonated amorphous carbons derived from wood powder. Catalysis Communications. 2017, 96: 32–36. ISSN 1566-7367. doi:10.1016/j.catcom.2017.03.015.

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