SH3結構域

SH3結構域(英語:SH3 domain,全稱Src同源3結構域,英語:SRC Homology 3 Domain)是最早在病毒接頭蛋白v-Crk及酪氨酸激酶SrcAbl中發現的長約60個氨基酸殘基的保守結構域[1][2],在磷酸肌醇3-激酶Ras超家族G蛋白cdc25中也存在[3][4][5]

SH3 domain
α-血影蛋白的SH3結構域的飄帶圖,PDB代碼1SHG,N-端為藍色,C-端為紅色
鑑定
標誌SH3_1
PfamPF00018舊版
Pfam宗系CL0010舊版
InterPro英語InterProIPR001452
SMART英語Simple Modular Architecture Research ToolSM00326
PROSITE英語PROSITEPS50002
SCOP英語Structural Classification of Proteins1shf / SUPFAM
CDD英語Conserved Domain Databasecd00174

參考文獻

  1. ^ Pawson T, Schlessingert J. SH2 and SH3 domains. Current Biology. July 1993, 3 (7): 434–42. PMID 15335710. doi:10.1016/0960-9822(93)90350-W. 
  2. ^ Mayer, B.J. SH3 domains: complexity in moderation. Journal of Cell Science. 2001-04, 114 (7): 1253–1263 [2023-03-10]. PMID 11256992. doi:10.1242/jcs.114.7.1253. (原始內容存檔於2023-03-10). 
  3. ^ Musacchio A, Gibson T, Lehto VP, Saraste M. SH3--an abundant protein domain in search of a function. FEBS Letters. July 1992, 307 (1): 55–61. PMID 1639195. doi:10.1016/0014-5793(92)80901-R. 
  4. ^ Mayer BJ, Baltimore D. Signalling through SH2 and SH3 domains. Trends in Cell Biology. January 1993, 3 (1): 8–13. PMID 14731533. doi:10.1016/0962-8924(93)90194-6. 
  5. ^ Pawson T. Protein modules and signalling networks. Nature. February 1995, 373 (6515): 573–80. PMID 7531822. doi:10.1038/373573a0. 

外部連結