牛肉牛乳因子

牛肉牛乳因子(英语:bovine meat and milk factors,简称BMMF)是在陆生哺乳动物[1][2][来源请求]肉和奶中常见的环状DNA,和结肠癌乳腺癌的形成有关[3]

潜在来源

细菌体内的质粒是一种复制子,类似于被整合入细菌体内的共生病毒。不动杆菌是一类广泛存在于土壤中的细菌,可被牛只摄入,鲍曼不动杆菌被发现存在于21.1%的德国乳用牛种及6.8%的肉用牛种中[4],其质粒DNA为环状。牛肉牛乳因子作为一类环状DNA,与这种质粒DNA具有相似性[5],与矮化病毒科双生病毒科单链DNA病毒的DNA亦具相似性。[6]

人体内作用机理

牛肉牛乳因子和癌症的潜在关系是由在海德堡大学德国癌症研究中心德语Deutsches Krebsforschungszentrum工作的哈拉尔德·楚尔·豪森和Ethel-Michele de Villiers,其基础是以流行病学资料的评估[7][8][9]以及人类血清白蛋白抗体的探讨[10][11]为基础。研究也指出牛肉牛乳因子和神经退化障碍(例如多发性硬化症)有潜在关系[10]

DKFZ的Timo Bund的工作组在2017年年底,透过识别牛肉牛乳因子的RNA以及其蛋白质产物,证明牛肉牛乳因子在人类细胞中可以长期存留[10][12]

2019年2月时,Ethel-Michele de Villiers在欧亚牛的血清和牛奶中找到新发现的病原体,可能会间接引发结肠癌的发展[8][13]

参考资料

  1. ^ 包含常见的猪肉、黄牛肉、羊肉、马肉。
  2. ^ Falida, Konstantina. Identification of single-stranded DNAs from beef products, their replication in human cells and their relationship with breast cancer (DSc论文). Heidelberg University. 2019-12-11 [2021-03-22]. (原始内容存档于2020-07-18). 
  3. ^ Episomal-Persistent DNA in Cancer- and Chronic Diseases. Deutsches Krebsforschungszentrum. [2021-03-03]. (原始内容存档于2021-03-16). 
  4. ^ Seasonal Occurrence and Carbapenem Susceptibility of Bovine Acinetobacter baumannii in Germany
  5. ^ Analysis of chronic inflammatory lesions of the colon for BMMF Rep antigen expression and CD68 macrophage interactions. [2021-03-22]. (原始内容存档于2021-03-19). 
  6. ^ A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue. [2021-03-22]. (原始内容存档于2019-11-15). 
  7. ^ Hausen, Harald zur; Villiers, Ethel-Michele de. Dairy cattle serum and milk factors contributing to the risk of colon and breast cancers. International Journal of Cancer. 2015, 137 (4): 959–967. ISSN 1097-0215. doi:10.1002/ijc.29466 (英语). 
  8. ^ 8.0 8.1 Hausen, Harald zur; Bund, Timo; Villiers, Ethel-Michele de. Specific nutritional infections early in life as risk factors for human colon and breast cancers several decades later. International Journal of Cancer. 2019, 144 (7): 1574–1583 [2021-03-22]. ISSN 1097-0215. doi:10.1002/ijc.31882. (原始内容存档于2019-06-04) (英语). 
  9. ^ Däuble, Wolfgang. Nobelpreisträger zur Hausen: Warum haben Inder so selten Darmkrebs? [Nobel laureate zur Hausen: Why do Indians so rarely have colon cancer?]. FAZ.NET. [2021-03-03]. ISSN 0174-4909 (德语). 
  10. ^ 10.0 10.1 10.2 Eilebrecht, Sebastian; Hotz-Wagenblatt, Agnes; Sarachaga, Victor; Burk, Amelie; Falida, Konstantina; Chakraborty, Deblina; Nikitina, Ekaterina; Tessmer, Claudia; Whitley, Corinna; Sauerland, Charlotte; Gunst, Karin. Expression and replication of virus-like circular DNA in human cells. Scientific Reports. 2018-02-12, 8 (1): 2851 [2021-03-22]. ISSN 2045-2322. doi:10.1038/s41598-018-21317-w . (原始内容存档于2021-03-16) (英语). 
  11. ^ Erhöhtes Krebsrisiko durch Kuhmilch und Rindfleisch? [Increased cancer risk from cow's milk and beef?]. AerzteZeitung.de. [2021-03-03]. (原始内容存档于2020-11-27) (德语). 
  12. ^ Episomal-Persistierende DNA in Krebs- und chronischen Erkrankungen. Deutsches Krebsforschungszentrum. [2021-03-03]. (原始内容存档于2021-04-15). 
  13. ^ Risikofaktor für Darmkrebs in Milch entdeckt [Colon cancer risk factor discovered in milk]. CME. 2019, (4) (德语).