血小板衍生生长因子受体

血小板衍生生长因子受体(Platelet-derived growth factor receptors,PDGF-R)为血小板衍生生长因子(PDGF)蛋白质家族的受体,位于细胞膜表面,属于酪胺酸激酶受体英语receptor tyrosine kinase的一种。PDGF的次单元A次单元B在调控细胞增殖分化生长发育上扮演相当重要的角色。如果调控不正常,可能会引发癌症等多种疾病。[2]

血小板衍生生长因子受体的α链英语PDGFRA
识别
符号 PDGFRA
Entrez 5156
HUGO 8803
OMIM 173490
RefSeq NM_006206
UniProt P16234
其他资料
基因座 4 q12
血小板衍生生长因子受体的β链英语PDGFRB
Ribbon image of two molecules of human PDGF receptor beta (yellow and magenta) in complex with dimeric PDGF-B (cyan and green).[1]
识别
符号 PDGFRB
替换符号 PDGFR
Entrez 5159
HUGO 8804
OMIM 173410
RefSeq NM_002609
UniProt P09619
其他资料
基因座 5 q31-q32

PDGF-R有两种型态,分别为AB,两种型态来自于不同基因。[3]由于PDRF-R必须由两者结合成为双体之后才能作用,因此PDGFRA和PDGFRB可以互相组合或自我组合为均聚物(homodimerizes,即A配A、B配B)或杂二聚物(heterodimerizes,即A配B)[4]

参见

参考资料

  1. ^ PDB 3MJG; Shim, Ann Hye-Ryong; Liu, Heli; Focia, Pamela J.; Chen, Xiaoyan; Lin, P. Charles; He, Xiaolin. Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proceedings of the National Academy of Sciences. 2010, 107 (25): 11307–12. ISSN 0027-8424. PMC 2895058 . PMID 20534510. doi:10.1073/pnas.1000806107. ; rendered using PyMOL页面存档备份,存于互联网档案馆).
  2. ^ Williams LT. Signal transduction by the platelet-derived growth factor receptor. Science. March 1989, 243 (4898): 1564–70. PMID 2538922. doi:10.1126/science.2538922. 
  3. ^ Heldin CH, Westermark B. Platelet-derived growth factor: three isoforms and two receptor types. Trends Genet. April 1989, 5 (4): 108–11. PMID 2543106. doi:10.1016/0168-9525(89)90040-1. 
  4. ^ Heldin CH, Ostman A, Eriksson A, Siegbahn A, Claesson-Welsh L, Westermark B. Platelet-derived growth factor: isoform-specific signalling via heterodimeric or homodimeric receptor complexes. Kidney Int. March 1992, 41 (3): 571–4. PMID 1315403. doi:10.1038/ki.1992.84. 

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