7,8-二羟基黄酮

化合物

7,8-二羟基黄酮(英语:7,8-Dihydroxyflavone,缩写7,8-DHF,也称为 Tropoflavin)是一种天然黄酮,存在于长柄菊(学名:Tridax procumbens)等植物中[2][3][4]

Tropoflavin
药物动力学数据
生物利用度~5% (in mice)[1]
生物半衰期< 30 minutes (in mice)[1]
识别信息
  • 7,8-Dihydroxy-2-phenyl-4H-chromen-4-one
CAS号38183-03-8  checkY
PubChem CID
ChemSpider
UNII
ChEBI
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.048.903 编辑维基数据链接
化学信息
化学式C15H10O4
摩尔质量254.24 g·mol−1
3D模型(JSmol英语JSmol
  • c1ccc(cc1)c2cc(=O)c3ccc(c(c3o2)O)O
  • InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
  • Key:COCYGNDCWFKTMF-UHFFFAOYSA-N

参考文献

  1. ^ 1.0 1.1 US application 20150274692,Keqiang Ye,“7,8-Dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto”,发表于2015-10-01,指定于Emory University 
  2. ^ Andero, R.; Ressler, K.J. Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes, Brain and Behavior. 2012, 11 (5): 503–512. ISSN 1601-1848. PMC 3389160 . PMID 22530815. doi:10.1111/j.1601-183X.2012.00801.x. 
  3. ^ Colombo, Paola S.; Flamini, Guido; Christodoulou, Michael S.; Rodondi, Graziella; Vitalini, Sara; Passarella, Daniele; Fico, Gelsomina. Farinose alpine Primula species: Phytochemical and morphological investigations (PDF). Phytochemistry. 2014, 98: 151–159. ISSN 0031-9422. PMID 24345641. doi:10.1016/j.phytochem.2013.11.018. hdl:2434/233766 . 
  4. ^ Cell Press. Molecule found in tree leaves helps female mice combat weight gain; males unaffected. ScienceDaily. 2015 [2015-03-19]. (原始内容存档于2021-07-26).