Γ-谷氨酰水解酶

Γ-谷氨酰水解酶
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1L9X
识别号
别名	GGH；, GH, gamma-glutamyl hydrolase, GATD10
外部ID	OMIM：601509 MGI：1329035 HomoloGene：2881 GeneCards：GGH
基因位置（人类）
染色体	8号染色体
终止	63,039,407 bp
基因位置（小鼠）
染色体	小鼠4号染色体
终止	20,066,750 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• exopeptidase activity; • omega peptidase activity; • 水解酶活性; • gamma-glutamyl-peptidase activity;
细胞组分	• 黑色素体; • 细胞质基质; • 溶酶体; • 外排体; • 细胞核; • 细胞外区域; • 细胞外空间; • azurophil granule lumen; • specific granule lumen; • tertiary granule lumen; • 液泡;
生物学过程	• response to insulin; • response to zinc ion; • response to ethanol; • 蛋白酶解; • neutrophil degranulation; • tetrahydrofolylpolyglutamate metabolic process;
	Sources:Amigo / QuickGO
直系同源
	8836
	14590
	ENSG00000137563
	ENSMUSG00000073987
	Q92820
	Q9Z0L8
	NM_003878
	NM_010281
	NP_003869
	NP_034411
	维基数据
查看/编辑人类	查看/编辑小鼠

γ-谷氨酰水解酶
命名
系统命名
缩写
识别码
EC编号	3.4.19.9
CAS号	9074-87-7
数据库
IntEnz	IntEnz浏览
BRENDA（英语：BRENDA）	BRENDA入口
ExPASy（英语：ExPASy）	NiceZyme浏览
KEGG	KEGG入口
MetaCyc（英语：MetaCyc）	代谢路径
PRIAM（英语：PRIAM_enzyme-specific_profiles）	概述
PDB	RCSB PDB PDBj PDBe PDBsum
搜索
PMC	相关文献
PubMed	相关文献

γ-谷氨酰水解酶（英文：Gamma-glutamyl hydrolase）是一种催化以下化学反应的酶^[5]^[6]^[7]^[8]：

γ-谷氨酰键的水解

这种溶酶体或分泌的硫醇依赖性肽酶，在酸性 pH值下最活跃。

在人类中，γ-谷氨酰水解酶由GGH基因编码。^[7]^[9]^[10]该基因通过去除γ联聚谷氨酸和谷氨酸来催化叶酰聚-γ-谷氨酸和抗叶酰聚-γ-谷氨酸的水解。^[10]

互动通路图

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000137563 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000073987 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J. The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells. Biochim. Biophys. Acta. August 1993, 1164 (3): 227–35. PMID 8343522. doi:10.1016/0167-4838(93)90253-n.
^ Yao R, Rhee MS, Galivan J. Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells. Mol. Pharmacol. September 1995, 48 (3): 505–11. PMID 7565632.
^ ^7.0 ^7.1 Yao R, Schneider E, Ryan TJ, Galivan J. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. Proc. Natl. Acad. Sci. U.S.A. September 1996, 93 (19): 10134–8. PMC 38349  . PMID 8816764. doi:10.1073/pnas.93.19.10134  .
^ Yao R, Nimec Z, Ryan TJ, Galivan J. Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. J. Biol. Chem. April 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525  .
^ Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R. Structural organization of the human gamma-glutamyl hydrolase gene. Gene. Dec 1999, 238 (2): 463–70. PMID 10570974. doi:10.1016/S0378-1119(99)00362-5.
^ ^10.0 ^10.1 Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase). [2022-12-12]. （原始内容存档于2022-12-12）.

拓展阅读

Galivan J, Ryan T, Rhee M, et al. Glutamyl hydrolase: properties and pharmacologic impact. Semin. Oncol. 1999, 26 (2 Suppl 6): 33–7. PMID 10598552.
O'Connor BM, Rotundo RF, Nimec Z, et al. Secretion of gamma-glutamyl hydrolase in vitro. Cancer Res. 1991, 51 (15): 3874–81. PMID 1713122.
Chandler CJ, Wang TT, Halsted CH. Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization. J. Biol. Chem. 1986, 261 (2): 928–33. PMID 2867095. doi:10.1016/S0021-9258(17)36185-9  .
Wang TT, Chandler CJ, Halsted CH. Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization. J. Biol. Chem. 1986, 261 (29): 13551–5. PMID 3759978. doi:10.1016/S0021-9258(18)67054-1  .
Yao R, Nimec Z, Ryan TJ, Galivan J. Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. J. Biol. Chem. 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525  .
Rhee MS, Lindau-Shepard B, Chave KJ, et al. Characterization of human cellular gamma-glutamyl hydrolase. Mol. Pharmacol. 1998, 53 (6): 1040–6. PMID 9614206.
Li H, Ryan TJ, Chave KJ, Van Roey P. Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate. J. Biol. Chem. 2002, 277 (27): 24522–9. PMID 11953431. doi:10.1074/jbc.M202020200  .
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899  .
Basrur V, Yang F, Kushimoto T, et al. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. J. Proteome Res. 2003, 2 (1): 69–79. PMID 12643545. doi:10.1021/pr025562r.
Gerhard DS, Wagner L, Feingold EA, et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928  . PMID 15489334. doi:10.1101/gr.2596504.
He P, Varticovski L, Bowman ED, et al. Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. Hum. Pathol. 2004, 35 (10): 1196–209 [2022-12-12]. PMID 15492986. doi:10.1016/j.humpath.2004.06.014. （原始内容存档于2022-10-15）.
Rual JF, Venkatesan K, Hao T, et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005, 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. S2CID 4427026. doi:10.1038/nature04209.
Eisele LE, Chave KJ, Lehning AC, Ryan TJ. Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer. Biochim. Biophys. Acta. 2006, 1764 (9): 1479–86. PMID 16945597. doi:10.1016/j.bbapap.2006.06.008.
Chi A, Valencia JC, Hu ZZ, et al. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J. Proteome Res. 2007, 5 (11): 3135–44. PMID 17081065. doi:10.1021/pr060363j.
Hayashi H, Fujimaki C, Inoue K, et al. Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population. Biol. Pharm. Bull. 2007, 30 (4): 839–41. PMID 17409534. doi:10.1248/bpb.30.839  .

外部链接

医学主题词表（MeSH）：Gamma-glutamyl+hydrolase
PDB中UniProt可用的所有结构信息之概述：Q92820 (Gamma-glutamyl hydrolase) 在PDBe-KB（英语：PDBe-KB）。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000137563 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000073987 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8343522-5] Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J. The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells. Biochim. Biophys. Acta. August 1993, 1164 (3): 227–35. PMID 8343522. doi:10.1016/0167-4838(93)90253-n.

[pmid7565632-6] Yao R, Rhee MS, Galivan J. Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells. Mol. Pharmacol. September 1995, 48 (3): 505–11. PMID 7565632.

[pmid8816764-7] 7.0 ^7.1 Yao R, Schneider E, Ryan TJ, Galivan J. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. Proc. Natl. Acad. Sci. U.S.A. September 1996, 93 (19): 10134–8. PMC 38349  . PMID 8816764. doi:10.1073/pnas.93.19.10134  .

[pmid8621474-8] Yao R, Nimec Z, Ryan TJ, Galivan J. Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. J. Biol. Chem. April 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525  .

[pmid10570974-9] Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R. Structural organization of the human gamma-glutamyl hydrolase gene. Gene. Dec 1999, 238 (2): 463–70. PMID 10570974. doi:10.1016/S0378-1119(99)00362-5.

[entrez-10] 10.0 ^10.1 Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase). [2022-12-12]. （原始内容存档于2022-12-12）.

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