特他洛尔

化合物

特他洛尔(英语:Tertatolol),商品名Artex、Artexal、Prenalex,是一种β受体阻滞剂,用于治疗高血压。它是由法国施维雅制药公司发现的,并在欧洲销售。[1]

特他洛尔
临床资料
AHFS/Drugs.com国际药品名称
给药途径口服
ATC码
法律规范状态
法律规范
  • 处方药(-only)
识别信息
  • (±)-1-(tert-Butylamino)-3-(3,4-dihydro-2H-thiochromen-8-yloxy)propan-2-ol
CAS号83688-84-0  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.073.179 编辑维基数据链接
化学信息
化学式C16H25NO2S
摩尔质量295.44 g·mol−1
3D模型(JSmol英语JSmol
手性外消旋体
  • CC(C)(C)NCC(COC1=CC=CC2=C1SCCC2)O
  • InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 ☒N
  • Key:HTWFXPCUFWKXOP-UHFFFAOYSA-N ☒N

特他洛尔还被证明可作为血清素5-HT1A5-HT1B受体拮抗剂,类似于普萘洛尔吲哚洛尔[2][3][4]

参见

参考资料

  1. ^ Swiss Pharmaceutical Society. Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. 2000. ISBN 3-88763-075-0. 
  2. ^ Langlois M, Brémont B, Rousselle D, Gaudy F. Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors. European Journal of Pharmacology. January 1993, 244 (1): 77–87. PMID 8093601. doi:10.1016/0922-4106(93)90061-d. 
  3. ^ Jolas T, Haj-Dahmane S, Lanfumey L, Fattaccini CM, Kidd EJ, Adrien J, et al. (-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology. May 1993, 347 (5): 453–463. PMID 7686633. S2CID 22129922. doi:10.1007/bf00166735. 
  4. ^ van Wijngaarden I, Soudijn W, Tulp MT. 5-HT1A Receptors. Soudijn W, Olivier B, van Wijngaarden I (编). Serotonin Receptors and Their Ligands. Amsterdam: Elsevier. 1997. ISBN 0-444-82041-8. 

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