苯奈达林

化合物

苯奈达林(英语:Binedaline或binodaline)是一种含氮有机化合物,分子式C19H23N3,通常以盐酸盐的形式存在[1],能用作抗抑郁药[2],从未上市销售[3]

苯奈达林
临床资料
给药途径Oral
ATC码
  • 未分配
法律规范状态
法律规范
  • Unscheduled
识别信息
  • N,N,N-Trimethyl-N-(3-phenylindol-1-yl)ethane-1,2-diamine
CAS号60662-16-0  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C19H23N3
摩尔质量293.41 g·mol−1
3D模型(JSmol英语JSmol
  • c1cccc2c1c(cn2N(CCN(C)C)C)c3ccccc3
  • InChI=1S/C19H23N3/c1-20(2)13-14-21(3)22-15-18(16-9-5-4-6-10-16)17-11-7-8-12-19(17)22/h4-12,15H,13-14H2,1-3H3 checkY
  • Key:SXYFFMXPDDGOEK-UHFFFAOYSA-N checkY
合成方式:[4][5][6]

参考文献

  1. ^ Milne GW. 3043: Binedaline hydrochloride. Milne GW (编). Drugs: Synonyms and Properties. Routledge. 2017. ISBN 9781351755092. 
  2. ^ Faltus F, Geerling FC. A controlled double-blind study comparing binedaline and imipramine in the treatment of endogenous depression. Neuropsychobiology. 1984, 12 (1): 34–38. PMID 6239991. doi:10.1159/000118107. 
  3. ^ Triggle DJ. Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. 1996. ISBN 0-412-46630-9. 
  4. ^ Schatz F, Jahn U, Wagner-Jauregg T, Zirngibl L, Thiele K. 1-amino-3-phenylindoles with antidepressant activity. Binodaline hydrochloride and related substances. Arzneimittel-Forschung. 1980, 30 (6): 919–923. PMID 7191264. doi:10.1002/chin.198038207. 
  5. ^ DE 2512702,Fischer K, Jahn U, Schatz F, Stammbach C, Thiele K, Wagner-Jauregg T. Zirngibl L,“New Hydrazines and Methods of Manufacturing Them”,发行于23 September 1982,指定于Siegfried AG 
  6. ^ US 4204998,Schatz F, Stammbach C, Thiele K, Theodor W. Wagner-Jauregg, Zirngibl L, Fischer J, Jahn U,“N-Amino indole derivatives having pharmacological activity”,发行于27 May 1980,指定于Siegfried AG 

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