血浆铜蓝蛋白
血浆铜蓝蛋白（英语：Ceruloplasmin）又称铜蓝血浆蛋白、铜蓝蛋白，由肝脏细胞制造，重约151千道尔顿(kDa)，包含六个铜离子。
| 血浆铜蓝蛋白(ferroxidase) | |||||||||||||
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 PDB rendering based on 1kcw. | |||||||||||||
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| 标识 | |||||||||||||
| 代号 | CP; CP-2 | ||||||||||||
| 扩展标识 | 遗传学：117700 鼠基因：88476 同源基因：75 GeneCards: CP Gene | ||||||||||||
| EC编号 | 1.16.3.1 | ||||||||||||
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| RNA表达模式 | |||||||||||||
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| 更多表达数据 | |||||||||||||
| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 1356 | 12870 | |||||||||||
| Ensembl | ENSG00000047457 | ENSMUSG00000003617 | |||||||||||
| UniProt | P00450 | Q61147 | |||||||||||
| mRNA序列 | NM_000096 | NM_001042611 | |||||||||||
| 蛋白序列 | NP_000087 | NP_001036076 | |||||||||||
| 基因位置 |
Chr 3: 148.88 – 148.94 Mb |
Chr 3: 19.96 – 20.01 Mb | |||||||||||
| PubMed查询 | [1] | [2] | |||||||||||
概要
在血液中，血浆铜蓝蛋白携带了90%的铜离子，另外10%由白蛋白携带。血浆铜蓝蛋白的主要作用是进行依赖铜离子的氧化反应，反应时将二价铜离子还原成一价，而把铁离子由二价氧化成三价，成为可以与运铁蛋白结合的型态。
因为血浆铜蓝蛋白是由肝脏制造，所以当有肝脏疾病时其含量就会下降。或是因为基因缺陷而无法制造，如肝豆状核变性（威尔森氏症）、原血浆铜蓝蛋白缺乏症等，多数（80～95%）肝豆状核变性患者血浆铜蓝蛋白呈现下降。在怀孕、淋巴瘤、慢性发炎、类风湿性关节炎的情况下，血浆铜蓝蛋白在血液中的含量则会上升。
延伸阅读
注释
参考文献
- Gropper, Smith, Groff. Advanced Nutrition And Human Metabolism 5th ed.
延伸阅读
- Hellman NE, Gitlin JD. Ceruloplasmin metabolism and function. Annual Review of Nutrition. 2002, 22: 439–58. PMID 12055353. doi:10.1146/annurev.nutr.22.012502.114457.
- Mazumder B, Seshadri V, Fox PL. Translational control by the 3'-UTR: the ends specify the means. Trends in Biochemical Sciences. Feb 2003, 28 (2): 91–8. PMID 12575997. doi:10.1016/S0968-0004(03)00002-1.
- Giurgea N, Constantinescu MI, Stanciu R, Suciu S, Muresan A. Ceruloplasmin - acute-phase reactant or endogenous antioxidant? The case of cardiovascular disease. Medical Science Monitor. Feb 2005, 11 (2): RA48–51. PMID 15668644.
- Kingston IB, Kingston BL, Putnam FW. Chemical evidence that proteolytic cleavage causes the heterogeneity present in human ceruloplasmin preparations. Proceedings of the National Academy of Sciences of the United States of America. Dec 1977, 74 (12): 5377–81. PMC 431726
. PMID 146197. doi:10.1073/pnas.74.12.5377. - Polosatov MV, Klimov PK, Masevich CG, Samartsev MA, Wünsch E. Interaction of synthetic human big gastrin with blood proteins of man and animals. Acta Hepato-Gastroenterologica. Apr 1979, 26 (2): 154–9. PMID 463490.
- Schilsky ML, Stockert RJ, Pollard JW. Caeruloplasmin biosynthesis by the human uterus. The Biochemical Journal. Dec 1992, 288 (2): 657–61. PMC 1132061 . PMID 1463466. doi:10.1042/bj2880657.
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