4-甲氧基雌三醇
4-甲氧基雌三醇(英语:4-Methoxyestriol,缩写4-ME3)是一种内源性的雌激素雌三醇的代谢产物[1][2][3][4]。4-ME3可看作是4-羟基雌三醇的4-甲基醚[1][2][3]。4-甲氧基雌三醇对雌激素受体的亲和力非常低[4]其对ERα和ERβ的相对亲和力(RBAs)只有雌二醇的约1%[4],相比之下,雌三醇对ERα和ERβ两者的RBAs为11%和35%[4]。
4-甲氧基雌三醇 | |
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IUPAC名 (8R,9S,13S,14S,16R,17R)-4-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol | |
别名 | 4-MeO-E3; 4-Methoxyestra-1,3,5(10)-triene-3,16α,17β-triol |
识别 | |
CAS号 | 101534-28-5 ![]() |
PubChem | 9901559 |
ChemSpider | 8077213 |
SMILES |
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InChI |
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InChIKey | MTZUPVFOGAXGJG-JUVWIQMMSA-N |
性质 | |
化学式 | C19H26O4 |
摩尔质量 | 318.41 g·mol−1 |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
参考资料
- ^ 1.0 1.1 Gerhardt K, Ludwig-Köhn H, Henning HV, Remberg G, Zeeck A. Identification of oestrogen metabolites in human urine by capillary gas chromatography and mass spectrometry. Biomed. Environ. Mass Spectrom. February 1989, 18 (2): 87–95. PMID 2706375. doi:10.1002/bms.1200180202.
- ^ 2.0 2.1 Gaikwad NW. Ultra performance liquid chromatography-tandem mass spectrometry method for profiling of steroid metabolome in human tissue. Anal. Chem. May 2013, 85 (10): 4951–60. PMID 23597399. doi:10.1021/ac400016e.
- ^ 3.0 3.1 Fujii Y, Teranishi M, Nakada K, Yamazaki M, Kishida S, Miyabo S. Radioimmunoassay for the determination of 2-methoxyestriol concentration in plasma of pregnant women. Chem. Pharm. Bull. February 1992, 40 (2): 410–3. PMID 1606638. doi:10.1248/cpb.40.410 .
- ^ 4.0 4.1 4.2 4.3 Zhu BT, Han GZ, Shim JY, Wen Y, Jiang XR. Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: Insights into the structural determinants favoring a differential subtype binding. Endocrinology. September 2006, 147 (9): 4132–50. PMID 16728493. doi:10.1210/en.2006-0113 .