A2780是分离于未接受任何治疗的人类女性卵巢癌患者上皮性卵巢细胞系[1],因对基质膜的粘附能力弱而具有强烈的迁移侵袭能力,故而恶性程度高。卵巢癌特异性结合 (OSTP) 对A2780细胞具有特异结合作用[2]。有研究指出新藤黄酸能诱导A2780细胞发生线粒体的凋亡,并且抑制细胞的生长及增殖[3]。同时又有研究指出敲除CKS2英语CKS2能够抑制A2780细胞中CDC42-V1 mRNA的表达,同时增强CDC42-V2 mRNA的表达,从而抑制丝足英语Filopodia的形成及细胞的迁移能力[4]

参考资料

  1. ^ Janczar, S; Graham, JS; Paige, AJW; Gabra, H. Targeting locoregional peritoneal dissemination in ovarian cancer. Expert Review of Obstetrics & Gynecology. 2014-01-10, 4 (2): 133–147. doi:10.1586/17474108.4.2.133. 
  2. ^ Yang, C; He, X; Liu, X; Tang, Z; Liang, X. OSTP as a novel peptide specifically targeting human ovarian cancer.. Oncology reports. 2015-08, 34 (2): 972–8 [2019-12-07]. PMID 26081347. doi:10.3892/or.2015.4066. 
  3. ^ CHENG Hui; LI Qing-lin; HOU Mei; SU Jing-jing. Effect of Gambogenic Acid on the Apoptosis of Ovarian Cancer Cell Line A2780. Journal of Anhui University of Chinese Medicine. 2019, (1): 58–62 [2019-12-07]. doi:10.3969/j.isn.2095-7246.2019.01.016. (原始内容存档于2019-12-07). 
  4. ^ Qian-ling, SUN; Meng-meng, DONG; YI, Yi; Jin-hui, HU; Mi-ni, ZHANG. Alternate title: CKS2 affects filopodia formation of A2780 cells through regulating CDC42 alternative splicing. Jie Fang Jun Yi Xue Za Zhi. 2016, 41 (8): 618–623. doi:10.11855/j.issn.0577-7402.2016.08.02. 

外部链接