CEBPG

CEBPG
识别号
别名	CEBPG；, GPE1BP, IG/EBP-1, CCAAT/enhancer binding protein gamma, CCAAT enhancer binding protein gamma
外部ID	OMIM：138972 MGI：104982 HomoloGene：1368 GeneCards：CEBPG
基因位置（人类）
染色体	19号染色体
终止	33,382,686 bp
基因位置（小鼠）
染色体	小鼠7号染色体
终止	34,755,998 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• DNA结合; • protein homodimerization activity; • DNA结合转录因子活性; • DNA-binding transcription activator activity, RNA polymerase II-specific; • 转录因子结合; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • 血浆蛋白结合; • sequence-specific DNA binding; • protein heterodimerization activity; • DNA-binding transcription factor activity, RNA polymerase II-specific; • double-stranded DNA binding; • RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending;
细胞组分	• 核质; • 细胞核;
生物学过程	• regulation of transcription, DNA-templated; • positive regulation of DNA repair; • positive regulation of DNA-binding transcription factor activity; • negative regulation of DNA-binding transcription factor activity; • transcription, DNA-templated; • enucleate erythrocyte differentiation; • 免疫反应; • mRNA metabolic process; • B cell differentiation; • positive regulation of DNA binding; • positive regulation of transcription by RNA polymerase II; • natural killer cell mediated cytotoxicity; • transcription by RNA polymerase II; • liver development; • regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
直系同源
	1054
	12611
	ENSG00000153879
	ENSMUSG00000056216
	P53567
	P53568
	NM_001806; NM_001252296
	NM_009884
	NP_001239225; NP_001797
	NP_034014
	维基数据
查看/编辑人类	查看/编辑小鼠

CCAAT/增强子结合蛋白γ，简称C/EBP-γ或CEBPG是一种在人体中由CEBPG基因编码的蛋白质。^[5]^[6]

C/EBP转录因子家族调节病毒和细胞CCAAT/增强子元件介导的转录。C/EBP蛋白包含bZIP区域，其特征在于蛋白质的C端一半中的两个基序：一个参与DNA结合的碱性区域和一个参与二聚化的亮氨酸拉链基序。 C/EBP家族由几种相关的蛋白质组成，即C/EBP-α、C/EBP-β、C/EBP-γ和C/EBP-δ，它们形成同源二聚体并相互形成异源二聚体。CEBPG可以与Fos合作以结合PRE-I增强子元件。^[6]

参见

CCAAT/增强子结合蛋白

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000153879 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000056216 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Williams SC, Cantwell CA, Johnson PF. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. Oct 1991, 5 (9): 1553–67. PMID 1884998. doi:10.1101/gad.5.9.1553  .
^ ^6.0 ^6.1 Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma. [2022-11-01]. （原始内容存档于2009-05-11）.

阅读

Nishizawa M, Nagata S. cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein.. FEBS Lett. 1992, 299 (1): 36–8. PMID 1371974. S2CID 34097395. doi:10.1016/0014-5793(92)80094-W  .
Thomassin H, Hamel D, Bernier D, et al. Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma.. Nucleic Acids Res. 1992, 20 (12): 3091–8. PMC 312443  . PMID 1377818. doi:10.1093/nar/20.12.3091.
Nishizawa M, Wakabayashi-Ito N, Nagata S. Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1.. FEBS Lett. 1991, 282 (1): 95–7. PMID 1709121. S2CID 948618. doi:10.1016/0014-5793(91)80452-9.
Cooper C, Henderson A, Artandi S, et al. Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators.. Nucleic Acids Res. 1996, 23 (21): 4371–7. PMC 307392  . PMID 7501458. doi:10.1093/nar/23.21.4371.
Davydov IV, Bohmann D, Krammer PH, Li-Weber M. Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter.. Gene. 1995, 161 (2): 271–5. PMID 7665092. doi:10.1016/0378-1119(95)00271-7.
Lundgren M, Larsson C, Femino A, et al. Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site.. J. Immunol. 1994, 153 (7): 2983–95. PMID 8089482.
Martin ML, Lieberman PM, Curran T. Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.. Mol. Cell. Biol. 1996, 16 (5): 2110–8. PMC 231198  . PMID 8628277. doi:10.1128/mcb.16.5.2110.
Gao H, Parkin S, Johnson PF, Schwartz RC. C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters.. J. Biol. Chem. 2002, 277 (41): 38827–37. PMID 12177065. doi:10.1074/jbc.M206224200  .
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899  .
Hattori T, Ohoka N, Inoue Y, et al. C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer.. Oncogene. 2003, 22 (9): 1273–80. PMID 12618752. doi:10.1038/sj.onc.1206204  .
Newman JR, Keating AE. Comprehensive identification of human bZIP interactions with coiled-coil arrays.. Science. 2003, 300 (5628): 2097–101. Bibcode:2003Sci...300.2097N. PMID 12805554. S2CID 36715183. doi:10.1126/science.1084648.
Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928  . PMID 15489334. doi:10.1101/gr.2596504.
Rual JF, Venkatesan K, Hao T, et al. Towards a proteome-scale map of the human protein-protein interaction network.. Nature. 2005, 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. S2CID 4427026. doi:10.1038/nature04209.
Mullins DN, Crawford EL, Khuder SA, et al. CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma.. BMC Cancer. 2006, 5: 141. PMC 1310620  . PMID 16255782. doi:10.1186/1471-2407-5-141.

外部链接

医学主题词表（MeSH）：CEBPG+protein,+human
Human CEBPG genome location and CEBPG gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000153879 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000056216 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1884998-5] Williams SC, Cantwell CA, Johnson PF. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. Oct 1991, 5 (9): 1553–67. PMID 1884998. doi:10.1101/gad.5.9.1553  .

[entrez-6] 6.0 ^6.1 Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma. [2022-11-01]. （原始内容存档于2009-05-11）.

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