8A-PDHQ

化合物

8A-PDHQ(全稱:8a-苯基十氫喹啉,英語:8a-Phenyldecahydroquinoline)是一種含氮有機化合物,分子式C15H21N,可作為NMDA受體拮抗劑,1950年代由Parke-Davis開發[1][2][3]

8A-PDHQ
識別資訊
  • 8a-phenyldecahydroquinoline
CAS號131556-11-1  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C15H21N
摩爾質量215.34 g·mol−1
3D模型(JSmol英語JSmol
  • C1([C@]23CCCC[C@H]2CCCN3)=CC=CC=C1
  • InChI=1S/C15H21N/c1-2-7-13(8-3-1)15-11-5-4-9-14(15)10-6-12-16-15/h1-3,7-8,14,16H,4-6,9-12H2 checkY
  • Key:QEXADSRMRUUCQJ-UHFFFAOYSA-N checkY

參考文獻

  1. ^ US Patent 3035059
  2. ^ Chen, C; Kozikowski, AP; Wood, PL; Reynolds, IJ; Ball, RG; Pang, YP. Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency.. Journal of medicinal chemistry. 1992-05-01, 35 (9): 1634–8. PMID 1315871. doi:10.1021/jm00087a020. 
  3. ^ Elhallaoui, M; Laguerre, M; Carpy, A; Ouazzani, FC. Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode.. Journal of molecular modeling. 2002-02, 8 (2): 65–72. PMID 12032600. doi:10.1007/s00894-001-0067-4.