S-18986
化合物
S-18986，是一種與環噻嗪相關的AMPA受體正變構調節劑。動物研究發現S-18986有促智和神經保護的作用，另外這種物質能誘導大腦海馬體及額葉皮層中腦源性神經營養因子和α-氨基-3-羥基-5-甲基-4-異惡唑丙酸（AMPA）介導去甲腎上腺素及乙醯膽鹼釋放。[1][2][3][4][5][6][7][8][9][10]
 | |
| 法律規範狀態 | |
|---|---|
| 法律規範 |
|
| 識別資訊 | |
| |
| CAS號 | 175340-20-2  |
| PubChem CID | |
| IUPHAR/BPS | |
| ChemSpider | |
| UNII | |
| CompTox Dashboard (EPA) | |
| 化學資訊 | |
| 化學式 | C10H12N2O2S |
| 摩爾質量 | 224.28 g·mol−1 |
| 3D模型（JSmol） | |
| |
| |
參見
參考文獻
- ^ (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices. European Journal of Pharmacology. August 2000, 401 (2): 145–53. PMID 10924919. doi:10.1016/S0014-2999(00)00433-7.
- ^ Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats. European Journal of Pharmacology. August 2000, 401 (2): 205–12. PMID 10924928. doi:10.1016/S0014-2999(00)00429-5.
- ^ Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain. Brain Research. April 2003, 970 (1–2): 221–5. PMID 12706264. doi:10.1016/S0006-8993(03)02357-6.
- ^ S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat. Neuroscience Letters. May 2004, 361 (1–3): 120–3. PMID 15135908. doi:10.1016/j.neulet.2003.12.061.
- ^ Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat. Drug Metabolism and Disposition. August 2005, 33 (8): 1137–43. PMID 15860654. doi:10.1124/dmd.105.004424.
- ^ Improvement of episodic contextual memory by S 18986 in middle-aged mice: comparison with donepezil. Psychopharmacology. July 2007, 193 (1): 63–73. PMID 17384936. doi:10.1007/s00213-007-0765-4.
- ^ The AMPA modulator S 18986 improves declarative and working memory performances in aged mice. Behavioural Pharmacology. May 2008, 19 (3): 235–44. PMID 18469541. doi:10.1097/FBP.0b013e3282feb0c1.
- ^ Effects of the AMPA receptor modulator S 18986 on measures of cognition and oxidative stress in aged rats. Psychopharmacology. January 2009, 202 (1–3): 225–35. PMID 18762915. doi:10.1007/s00213-008-1301-x.
- ^ GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986. Cell Death and Differentiation. April 2009, 16 (4): 624–37. PMID 19136940. doi:10.1038/cdd.2008.188.
- ^ The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis. Neuropharmacology. September 2009, 57 (3): 277–86. PMID 19501111. doi:10.1016/j.neuropharm.2009.05.010.