吡马卡林
化合物
吡马卡林（化学式：C17H14N2O2）是一种鉀離子通道開放劑。[1]
| Bimakalim | |
|---|---|
| |
| IUPAC名 2,2-Dimethyl-4-(2-oxopyridin-1(2H)-yl)-2H-1-benzopyran-6-carbonitrile | |
| 识别 | |
| CAS号 | 117545-11-6 
|
| PubChem | 60674 |
| ChemSpider | 54683 |
| SMILES |
|
| 性质 | |
| 化学式 | C17H14N2O2 |
| 摩尔质量 | 278.31 g·mol−1 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
合成与反应
吡马卡林可以3-乙酰基-4-羟基苯甲腈为原料，经多步反应制得。[2]它和二异丙氨基锂在四氢呋喃中反应，可以得到4-氰基-2-[1-(1,2-二氢-2-氧亚基-1-吡啶基)-3-甲基-1,2-丁二烯基]苯酚锂。[3]
参考文献
- ^ Puddu, Paolo Emilio; Garlid, Keith D; Monti, Francesco; Iwashiro, Katsunori; Picard, Sandra; Dawodu, Amos Adeyemo; Criniti, Anna; Ruvolo, Giovanni; Campa, Pietro Paolo. Bimakalim: A Promising KATP Channel Activating Agent. Cardiovascular Drug Reviews. 2006, 18: 25. doi:10.1111/j.1527-3466.2000.tb00031.x
.
- ^ Bergmann, Rolf; Gericke, Rolf. Synthesis and antihypertensive activity of 4-(1,2-dihydro-2-oxo-1-pyridyl)-2H-1-benzopyrans and related compounds, new potassium channel activators. Journal of Medicinal Chemistry (American Chemical Society (ACS)). 1990, 33 (2): 492–504. ISSN 0022-2623. doi:10.1021/jm00164a005.
- ^ Gericke, Rolf; Lues, Inge. The transformation of a chromene derivative into benzofurans via allene intermediates. Tetrahedron Letters (Elsevier BV). 1992, 33 (14): 1871–1874. ISSN 0040-4039. doi:10.1016/s0040-4039(00)74164-5.
