维基百科

四硝酸二氯六氨二(1,6-己二胺)合三铂

化合物

四硝酸二氯六氨二(1,6-己二胺)合三铂是一种配位化合物，化学式为[ClPt(NH3)2]2μ-{trans-Pt(NH3)2[H2N(CH2)6NH2]2}(NO3)4，有专利报道了它的合成。[1]它具有抗癌活性，在对三种卵巢瘤和四种黑色素瘤的研究中发现它的IC50比顺铂至少低20倍。[2]

四硝酸二氯六氨二(1,6-己二胺)合三铂
臨床資料
ATC碼
  • 未分配
识别信息
CAS号172903-00-3  checkY
UNII
ChEBI
化学信息
化学式C12H50Cl2N14O12Pt3
摩尔质量1,238.77 g·mol−1
3D模型（JSmol（英语：JSmol））
  • [O-][N+]([O-])=O.[O-][N+]([O-])=O.Cl[Pt-2]([NH3+])([NH3+])[NH2+]CCCCCC[NH2+][Pt-2]([NH3+])([NH3+])[NH2+]CCCCCC[NH2+][Pt-2]([NH3+])([NH3+])Cl.[O-][N+]([O-])=O.[O-][N+]([O-])=O

参考文献

  1. ^ Valsecchi, Mariella; Conti, Marco; Del Greco, Luisa; Bugatti, Carlo; Menta, Ernesto; Giuliani, Ferdinando C.; Manzotti, Carla; Spinelli, Silvano; Farrell, Nicholas. Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compositions containing them. 1995. WO9526968.
  2. ^ Carla Manzotti; Graziella Pratesi; Ernesto Menta; Roberto Di Domenico; Ennio Cavalletti; Heinz H. Fiebig; Lloyd R. Kelland; Nicholas Farrell; Donatella Polizzi; Rosanna Supino; Gabriella Pezzoni; Franco Zunino. BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin. Clin Cancer Res (2000) 6 (7): 2626–2634.

延伸阅读

  • Michael E. Oehlsen; Yun Qu; Nicholas Farrell. Reaction of Polynuclear Platinum Antitumor Compounds with Reduced Glutathione Studied by Multinuclear (1H, 1H−15N Gradient Heteronuclear Single-Quantum Coherence, and 195Pt) NMR Spectroscopy. Inorg. Chem. 2003, 42, 18, 5498–5506. doi:10.1021/ic030045b.
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