表皮生长因子

表皮生长因子（β-尿抑胃素）
表皮生长因子（β-尿抑胃素）
	Rainbow colored NMR structure (N-terminus = blue, C-terminus = red) of the mouse epidermal growth factor.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	human: 1JL9, 1IVO and 1NQL in complex with EGFR; mouse: 1EGF, 3EGF, 1EPG, 1EPH, 1EPI, 1EPJ; human EGF/TGF-α chimera: 1P9J; synthetic: 1A3P
标识
代号	EGF; URG
扩展标识	遗传学：131530 鼠基因：95290 同源基因：1483 GeneCards: EGF Gene
基因本体论描述
分子功能	· epidermal growth factor receptor-activating ligand activity; · calcium ion binding; · protein binding; · growth factor activity;
细胞成分	· extracellular region; · extracellular space; · nucleus; · plasma membrane; · integral to membrane;
生物过程	· activation of MAPKK activity; · activation of MAPK activity; · DNA replication; · chromosome organization and biogenesis (sensu Eukaryota); · epidermal growth factor receptor signaling pathway; · positive regulation of cell proliferation; · branching morphogenesis of a tube; · regulation of peptidyl-tyrosine phosphorylation;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	1950
Ensembl	ENSG00000138798
UniProt	P01133
mRNA序列	NM_001963
蛋白序列	NP_001954
基因位置	Chr 4:; 111.05 – 111.15 Mb
PubMed查询	[1]
	查; 论; 编;

表皮生长因子（英語：Epidermal growth factor，簡稱：EGF）是最早发现的生长因子，对调节细胞生长、增殖和分化起着重要作用。在人类，表皮生长因子蛋白有53个氨基酸残基，三个二硫键，质量6千道耳顿。^[2]

表皮生长因子通过与细胞表面的受体表皮生长因子受体（EGFR）结合而起作用。^[3]与表皮生长因子受体的高亲和力结合，激发受体内在的酪氨酸激酶的活性，从而启动了信号传导级联而导致多种生物化学变化，细胞内钙水平上升，增加糖酵解与蛋白质合成，增加某些基因（包括表皮生长因子受体）的表达，最终导致DNA合成和细胞增殖。^[2]

参考文献

^ PDB 1a3p; Barnham KJ, Torres AM, Alewood D, Alewood PF, Domagala T, Nice EC, Norton RS. Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor. Protein Science. August 1998, 7 (8): 1738–49. PMC 2144085  . PMID 10082370. doi:10.1002/pro.5560070808.
^ ^2.0 ^2.1 Epidermal growth factor. J Biol Chem. 1990; 265(14): 7709-12.
^ Downward J, Parker P, Waterfield MD. Autophosphorylation sites on the epidermal growth factor receptor. Nature. 1984 Oct 4-10;311(5985):483-5

外部链接

Human Protein Database=表皮生长因子（页面存档备份，存于互联网档案馆）
MeSH 表皮生长因子(英文)（页面存档备份，存于互联网档案馆）
Shaanxi Zhongbang Pharma-Tech Co., Ltd.-Supply of Epidermal Growth Factor（页面存档备份，存于互联网档案馆）
EGF at the Human Protein Reference Database.
醫學主題詞表（MeSH）：Epidermal+growth+factor
EGF model in BioModels database（页面存档备份，存于互联网档案馆）

[pmid10082370-1] PDB 1a3p; Barnham KJ, Torres AM, Alewood D, Alewood PF, Domagala T, Nice EC, Norton RS. Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor. Protein Science. August 1998, 7 (8): 1738–49. PMC 2144085  . PMID 10082370. doi:10.1002/pro.5560070808.

[cohen-2] 2.0 ^2.1 Epidermal growth factor. J Biol Chem. 1990; 265(14): 7709-12.

[3] Downward J, Parker P, Waterfield MD. Autophosphorylation sites on the epidermal growth factor receptor. Nature. 1984 Oct 4-10;311(5985):483-5

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