4,5,6,7-四氯-2-三氟甲基苯并咪唑

化合物

4,5,6,7-四氯-2-三氟甲基苯并咪唑是一种有机化合物,化学式为C8HCl4F3N2。它可由2-三氟甲基苯并咪唑和王水反应制得。[1]它和碘甲烷碳酸钾存在下于丙酮中回流,可以得到4,5,6,7-四氯-1-甲基-2-三氟甲基苯并咪唑。[3]

TTFB
识别
CAS号 2338-29-6  checkY
PubChem 75357
ChemSpider 67893
SMILES
 
  • C12=C(C(=C(C(=C1Cl)Cl)Cl)Cl)N=C(N2)C(F)(F)F
ChEBI 1744
KEGG C11322
性质
化学式 C8HCl4F3N2
摩尔质量 323.91 g·mol−1
外观 白色固体[1]
熔点 274-276 °C[1]
危险性
致死量或浓度:
LD50中位剂量
23 mg/kg(小鼠,腹膜)[2]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ 1.0 1.1 1.2 Laudy, Agnieszka E.; Moo‐Puc, Rosa; Cedillo‐Rivera, Roberto; Kazimierczuk, Zygmunt; Orzeszko, Andrzej. Synthesis and Antimicrobial Activities of New Polyhalogenated Benzimidazoles. Journal of Heterocyclic Chemistry (Wiley). 2012, 49 (5): 1059–1065. ISSN 0022-152X. doi:10.1002/jhet.936. 
  2. ^ Ilivicky, J; Casida, JE. Uncoupling action of 2,4-dinitrophenols, 2-trifluoromethylbenzimidazoles and certain other pesticide chemicals upon mitochondria from different sources and its relation to toxicity.. Biochemical Pharmacology. June 1969, 18 (6): 1389–401. PMID 5799112. doi:10.1016/0006-2952(69)90252-4. 
  3. ^ Kawazoe, Kentaro; Yoshioka, Kotaro. Fluoroalkylating agents, preparation of fluoroalkylated compounds using them, benzimidazolium salts for them, and their use. 2015. WO2015199109.