AB-PINACA
化合物
AB-PINACA是一种有机化合物，化学式为C18H26N4O2。它最初由辉瑞公司于2009年作为镇痛药开发，[1][2]并在2012年于日本首次被鉴定为合成大麻素。[3]
 | |
| 法律規範狀態 | |
|---|---|
| 法律規範 |
|
| 识别信息 | |
| |
| CAS号 | 1445752-09-9  |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| CompTox Dashboard (EPA) | |
| 化学信息 | |
| 化学式 | C18H26N4O2 |
| 摩尔质量 | 330.43 g·mol−1 |
| 3D模型（JSmol） | |
| |
| |
它是潜在的CB1受体（Ki = 2.87 nM，EC50 = 1.2 nM）和CB2受体（Ki = 0.88 nM，EC50 = 2.5 nM）的激动剂。[4][5]
这种合成大麻素有不少相关死亡和住院病例报告。[6]
参见
参考文献
- ^ AB-PINACA. Cayman Chemical. [25 June 2015]. （原始内容存档于2015-06-26）.
- ^ Patent WO/2009/106980 - Indazole derivatives. [2023-01-26]. （原始内容存档于2016-05-27）.
- ^ Uchiyama N, Matsuda S, Wakana D, Kikura-Hanajiri R, Goda Y. New cannabimimetic indazole derivatives, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA) identified as designer drugs in illegal products. Forensic Toxicology. 2012, 31: 93–100. S2CID 25242453. doi:10.1007/s11419-012-0171-4.
- ^ Banister SD, Moir M, Stuart J, Kevin RC, Wood KE, Longworth M, et al. Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA. ACS Chemical Neuroscience. September 2015, 6 (9): 1546–59. PMID 26134475. doi:10.1021/acschemneuro.5b00112.
- ^ Wiley JL, Marusich JA, Lefever TW, Antonazzo KR, Wallgren MT, Cortes RA, et al. AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in Mice. The Journal of Pharmacology and Experimental Therapeutics. September 2015, 354 (3): 328–39 [2023-01-26]. PMC 4538877
. PMID 26105953. doi:10.1124/jpet.115.225326. （原始内容存档于2023-01-30）.
- ^ Trecki J, Gerona RR, Schwartz MD. Synthetic Cannabinoid-Related Illnesses and Deaths. The New England Journal of Medicine. July 2015, 373 (2): 103–7. PMID 26154784. doi:10.1056/NEJMp1505328.
