E0771

E0771是C57BL/6小鼠髓樣乳腺癌 (Medullary breast adenocarcinoma) 細胞系，E0771細胞比4T1細胞具有更低的轉移能力，目前應用於多項研究當中。

科研用途

E0771細胞通常應用於C57BL/6小鼠乳腺癌的體外和體內研究^[1]。在2015年及2017年，分別有科研人員研究SDG補充劑 (SDG supplementation) 對在體內生長的E0771細胞的影響，發現SDG補充劑抑制着E0771細胞的生長，並且降低了核因子活化B細胞κ輕鏈增強子的腫瘤活性^[2]^[3]。2019年，有研究探討了白色脂肪組織褐變 (WAT褐變) 能否在體內的小鼠乳腺癌模型中發生，隨後研究了特徵明確的E0771細胞在體內的作用。實驗結果證明在體外的E0771細胞誘導着白色脂肪細胞基因表達模式的改變。WAT褐變不會通過直接的E0771癌細胞機制而發生。這表明腫瘤微環境中的細胞相互作用是致熱變化的潛在驅動力^[4]。

參考資料

^ Ewens, A; Mihich, E; Ehrke, MJ. Distant metastasis from subcutaneously grown E0771 medullary breast adenocarcinoma.. Anticancer research. NaN, 25 (6B): 3905–15 [2019-12-27]. PMID 16312045. （原始内容存档于2019-12-27）. 请检查|date=中的日期值 (帮助)
^ Johnstone, CN; Smith, YE; Cao, Y; Burrows, AD; Cross, RS; Ling, X; Redvers, RP; Doherty, JP; Eckhardt, BL; Natoli, AL; Restall, CM; Lucas, E; Pearson, HB; Deb, S; Britt, KL; Rizzitelli, A; Li, J; Harmey, JH; Pouliot, N; Anderson, RL. Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.. Disease models & mechanisms. 2015-03, 8 (3): 237–51 [2019-12-27]. PMID 25633981. doi:10.1242/dmm.017830. （原始内容存档于2019-12-27）.
^ Yang, Y; Yang, HH; Hu, Y; Watson, PH; Liu, H; Geiger, TR; Anver, MR; Haines, DC; Martin, P; Green, JE; Lee, MP; Hunter, KW; Wakefield, LM. Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis.. Oncotarget. 2017-05-09, 8 (19): 30621–30643 [2019-12-27]. PMID 28430642. doi:10.18632/oncotarget.15695. （原始内容存档于2019-12-27）.
^ Pearce, JV; Farrar, JS; Lownik, JC; Ni, B; Chen, S; Kan, TW; Celi, FS. E0771 and 4T1 murine breast cancer cells and interleukin 6 alter gene expression patterns but do not induce browning in cultured white adipocytes.. Biochemistry and biophysics reports. 2019-07, 18: 100624 [2019-12-27]. PMID 31193642. doi:10.1016/j.bbrep.2019.100624.

外部連結

Cellosaurus entry for E0771（页面存档备份，存于互联网档案馆）

[1] Ewens, A; Mihich, E; Ehrke, MJ. Distant metastasis from subcutaneously grown E0771 medullary breast adenocarcinoma.. Anticancer research. NaN, 25 (6B): 3905–15 [2019-12-27]. PMID 16312045. （原始内容存档于2019-12-27）. 请检查|date=中的日期值 (帮助)

[2] Johnstone, CN; Smith, YE; Cao, Y; Burrows, AD; Cross, RS; Ling, X; Redvers, RP; Doherty, JP; Eckhardt, BL; Natoli, AL; Restall, CM; Lucas, E; Pearson, HB; Deb, S; Britt, KL; Rizzitelli, A; Li, J; Harmey, JH; Pouliot, N; Anderson, RL. Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.. Disease models & mechanisms. 2015-03, 8 (3): 237–51 [2019-12-27]. PMID 25633981. doi:10.1242/dmm.017830. （原始内容存档于2019-12-27）.

[3] Yang, Y; Yang, HH; Hu, Y; Watson, PH; Liu, H; Geiger, TR; Anver, MR; Haines, DC; Martin, P; Green, JE; Lee, MP; Hunter, KW; Wakefield, LM. Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis.. Oncotarget. 2017-05-09, 8 (19): 30621–30643 [2019-12-27]. PMID 28430642. doi:10.18632/oncotarget.15695. （原始内容存档于2019-12-27）.

[4] Pearce, JV; Farrar, JS; Lownik, JC; Ni, B; Chen, S; Kan, TW; Celi, FS. E0771 and 4T1 murine breast cancer cells and interleukin 6 alter gene expression patterns but do not induce browning in cultured white adipocytes.. Biochemistry and biophysics reports. 2019-07, 18: 100624 [2019-12-27]. PMID 31193642. doi:10.1016/j.bbrep.2019.100624.

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