合胞素-1

位於7號人類染色體的基因

合胞素-1(Syncytin-1,enverin)是一种在人类和其他灵长类动物中发现的蛋白质,它由ERVW-1基因编码。 该基因是一种内源性病毒元件,它是2500万年前逆转录病毒感染人类后的残余物[3]。合胞素有助于胎盘发育[4][5][6]

合胞素-1
识别号
别名ERVW-1;, ENV, ENVW, ERVWE1, HERV-7q, HERV-W-ENV, HERV7Q, HERVW, HERVWENV, endogenous retrovirus group W member 1, endogenous retrovirus group W member 1, envelope
外部IDOMIM604659 HomoloGene137309 GeneCardsERVW-1
基因位置(人类
7号染色体
染色体7号染色体[1]
7号染色体
合胞素-1的基因位置
合胞素-1的基因位置
基因座7q21.2起始92,468,380 bp[1]
终止92,477,986 bp[1]
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_014590
​NM_001130925

无数据

蛋白序列

NP_001124397
​NP_055405

无数据

基因位置​(UCSC)Chr 7: 92.47 – 92.48 Mb无数据
PubMed​查找[2]无数据
维基数据
查看/编辑人类

参考文献

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000242950 - Ensembl, May 2017
  2. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ Phylogeny of a novel family of human endogenous retrovirus sequences, HERV-W, in humans and other primates. AIDS Research and Human Retroviruses. November 1999, 15 (17): 1529–33. PMID 10580403. doi:10.1089/088922299309810. 
  4. ^ From ancestral infectious retroviruses to bona fide cellular genes: role of the captured syncytins in placentation. Placenta. September 2012, 33 (9): 663–71. PMID 22695103. doi:10.1016/j.placenta.2012.05.005. 
  5. ^ The role of syncytins in human reproduction and reproductive organ cancers. Reproduction (Cambridge, England). 2016, 152 (5): R167–78. PMID 27486264. doi:10.1530/REP-16-0031. 
  6. ^ Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. September 2013, 368 (1626): 20120507. PMC 3758191 . PMID 23938756. doi:10.1098/rstb.2012.0507. 

外部链接