合胞素-1

位於7號人類染色體的基因

合胞素-1(Syncytin-1,enverin)是一種在人類和其他靈長類動物中發現的蛋白質,它由ERVW-1基因編碼。 該基因是一種內源性病毒元件,它是2500萬年前逆轉錄病毒感染人類後的殘餘物[3]。合胞素有助於胎盤發育[4][5][6]

合胞素-1
識別號
別名ERVW-1;, ENV, ENVW, ERVWE1, HERV-7q, HERV-W-ENV, HERV7Q, HERVW, HERVWENV, endogenous retrovirus group W member 1, endogenous retrovirus group W member 1, envelope
外部IDOMIM604659 HomoloGene137309 GeneCardsERVW-1
基因位置(人類
7號染色體
染色體7號染色體[1]
7號染色體
合胞素-1的基因位置
合胞素-1的基因位置
基因座7q21.2起始92,468,380 bp[1]
終止92,477,986 bp[1]
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_014590
​NM_001130925

無數據

蛋白序列

NP_001124397
​NP_055405

無數據

基因位置​(UCSC)Chr 7: 92.47 – 92.48 Mb無數據
PubMed​查找[2]無數據
維基數據
檢視/編輯人類

參考文獻

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000242950 - Ensembl, May 2017
  2. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ Phylogeny of a novel family of human endogenous retrovirus sequences, HERV-W, in humans and other primates. AIDS Research and Human Retroviruses. November 1999, 15 (17): 1529–33. PMID 10580403. doi:10.1089/088922299309810. 
  4. ^ From ancestral infectious retroviruses to bona fide cellular genes: role of the captured syncytins in placentation. Placenta. September 2012, 33 (9): 663–71. PMID 22695103. doi:10.1016/j.placenta.2012.05.005. 
  5. ^ The role of syncytins in human reproduction and reproductive organ cancers. Reproduction (Cambridge, England). 2016, 152 (5): R167–78. PMID 27486264. doi:10.1530/REP-16-0031. 
  6. ^ Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. September 2013, 368 (1626): 20120507. PMC 3758191 . PMID 23938756. doi:10.1098/rstb.2012.0507. 

外部鏈接