N-(5-硝基-2-吡啶基)乙二胺

N-(5-硝基-2-吡啶基)乙二胺是一种有机化合物,化学式为C7H10N4O2。它可由2-氯-5-硝基吡啶(或2-溴-5-硝基吡啶[1])和乙二胺乙腈中反应制得。[2]它和邻苯二甲酸酐三乙胺存在下于甲苯中回流,可以得到1,2,3,9b-四氢-1-(5-硝基-2-吡啶基)-5H-咪唑并[2,1-a]异吲哚-5-酮。[3]

N-(5-硝基-2-吡啶基)乙二胺
识别
CAS号 29602-39-9  checkY
PubChem 122425
SMILES
 
  • O=N(=O)C1=CN=C(C=C1)NCCN
性质
化学式 C7H10N4O2
摩尔质量 182.18 g·mol−1
熔点 123 °C(396 K)
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ Nonpeptide Somatostatin Agonists with sst4 Selectivity: Synthesis and Structure-Activity Relationships of Thioureas. Journal of Medicinal Chemistry (1998), 41(24), 4693-4705. doi:10.1021/jm980118e
  2. ^ Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3. Journal of Medicinal Chemistry (2017), 60(20), 8482-8514. doi:10.1021/acs.jmedchem.7b00922.
  3. ^ Cul, Armelle; Daich, Adam; Decroix, Bernard; Sanz, Gerard; Van Hijfte, Luc. Kinetic versus thermodynamic access to imidazoisoindolones, benzimidazoisoindolones, and [1,4]diazepinoisoindolones: intramolecular nitrogen and π-aromatic trapping of N-acyliminium cation. Tetrahedron. 2004. doi:10.1016/j.tet.2004.07.107.