CXCL11(英语:Chemokine (C-X-C motif) ligand 11)是一小分子的细胞因子属于CXC趋化因子家族[1],又被称作“干扰素诱导的T细胞a趋化因子”(Interferon-inducible T-cell alpha chemoattractant (I-TAC)[1]

Chemokine (C-X-C motif) ligand 11
PDB rendering based on 1rjt.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 CXCL11; H174; I-TAC; IP-9; IP9; SCYB11; SCYB9B; b-R1
扩展标识 遗传学604852 鼠基因1860203 同源基因3944 GeneCards: CXCL11 Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 6373 56066
Ensembl ENSG00000169248 n/a
UniProt O14625 Q9JHH5
mRNA序列 NM_005409 NM_019494.1
蛋白序列 NP_005400 NP_062367.1
基因位置 Chr 4:
76.95 – 76.96 Mb
n/a
PubMed查询 [1] [2]


表达

白细胞胰腺肝脏中表达水平高,在胸腺有中等水平的表达,在小肠胎盘前列腺中表达水平低[1]干扰素伽玛和干扰素-b可以在单核细胞[1],支气管上皮细胞[2]中性粒细胞[3],角质形成细胞[4],和内皮细胞诱导CXCL11的表达。


受体

CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用[1][5][6]。CXCL11也可以结合到趋化因子受体CCR3上而阻止CCR3配体的结合[7]


功能

CXCL11对活化的T细胞,中性粒细胞和单核细胞有细胞趋化作用[1]

参见

参考文献

  1. ^ 1.0 1.1 1.2 1.3 1.4 1.5 Cole et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J. Exp. Med. 187: 2009-2021, 1998.
  2. ^ Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K., Garcia-Zepeda, E. A., Hamid, Q., Luster, A. D. (1999) The T cell-specific CXC chemokines IP-10, MIG, and I-TAC are expressed by activated human bronchial epithelial cells J. Immunol. 162,3549-3558
  3. ^ Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L., Olsen, H., Murphy, M., Liao, F., Farber, J., Cassatella, M. A. (1999) Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils J. Immunol. 162,4928-4937.
  4. ^ Tensen, C. P., Flier, J., Van Der Raaij-Helmer, E. M., Sampat-Sardjoepersad, S., Van Der Schors, R. C., Leurs, R., Scheper, R. J., Boorsma, D. M., Willemze, R. (1999) Human IP-9: a keratinocyte-derived high-affinity CXC-chemokine ligand for the IP-10/MIG receptor (CXCR3) J. Invest. Dermatol. 112,716-72.
  5. ^ Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
  6. ^ Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
  7. ^ Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem. 2001 Feb 2;276(5):2986-91

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