細胞因子釋放綜合徵
細胞因子釋放綜合徵（CRS）是一種全身炎症反應綜合徵 (SIRS)，[1][2]當免疫系統與病原體作鬥爭時，大量白血球被激活並釋放促炎性細胞因子後，就有可能出現細胞因子釋放綜合徵。而此時這些促炎性細胞因子又會激活更多的白細胞。[3][4][5]
| 細胞因子釋放綜合徵 | |
|---|---|
| 又稱 | > |
| 類型 | 藥物不良反應、免疫系統疾病[*] |
| 分類和外部資源 | |
| 醫學專科 | 免疫學 |
| DiseasesDB | 34296 |
| eMedicine | 2500111 |
症狀和體徵
症狀包括發燒、疲勞、食欲不振、肌肉和關節疼痛、噁心、嘔吐、腹瀉、皮疹、呼吸急促、心動過速、低血壓、癲癇發作、頭痛、精神錯亂、譫妄、幻覺、震顫和失去協調。[3]
參考資料
- ^ Cytokine release syndrome. Journal for Immunotherapy of Cancer. June 2018, 6 (1): 56. PMC 6003181
. PMID 29907163. doi:10.1186/s40425-018-0343-9.
- ^ Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era. Arthritis & Rheumatology. June 2017, 69 (6): 1135–1143. PMID 28217930. doi:10.1002/art.40071.
- ^ 3.0 3.1 Current concepts in the diagnosis and management of cytokine release syndrome. Blood. July 2014, 124 (2): 188–95. PMC 4093680 . PMID 24876563. doi:10.1182/blood-2014-05-552729.
- ^ New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management. Critical Care. April 2017, 21 (1): 89. PMC 5391608 . PMID 28407743. doi:10.1186/s13054-017-1678-1.
- ^ Infusion reactions: diagnosis, assessment, and management. Clinical Journal of Oncology Nursing. April 2010, 14 (2): E10–21. PMID 20350882. doi:10.1188/10.CJON.E10-E21.
本文採用了美國衛生與公眾服務部文件中的公共領域材料: "Common Terminology Criteria for Adverse Events (CTCAE) Version v4.03"