細胞因子釋放綜合症

細胞因子釋放綜合症(CRS)是一種全身炎症反應綜合症 (SIRS),[1][2]免疫系統病原體作鬥爭時,大量白血球被激活並釋放促炎性細胞因子後,就有可能出現細胞因子釋放綜合症。而此時這些促炎性細胞因子又會激活更多的白細胞。[3][4][5]

細胞因子釋放綜合症
又稱>
類型藥物不良反應免疫系統疾病[*]
分類和外部資源
醫學專科免疫學
DiseasesDB34296
eMedicine2500111
[編輯此條目的維基數據]

症狀和體徵

症狀包括發燒、疲勞、食欲不振、肌肉和關節疼痛、噁心、嘔吐、腹瀉、皮疹、呼吸急促、心動過速、低血壓、癲癇發作、頭痛、精神錯亂、譫妄、幻覺、震顫和失去協調。[3]

參考資料

  1. ^ Cytokine release syndrome. Journal for Immunotherapy of Cancer. June 2018, 6 (1): 56. PMC 6003181 . PMID 29907163. doi:10.1186/s40425-018-0343-9. 
  2. ^ Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era. Arthritis & Rheumatology. June 2017, 69 (6): 1135–1143. PMID 28217930. doi:10.1002/art.40071. 
  3. ^ 3.0 3.1 Current concepts in the diagnosis and management of cytokine release syndrome. Blood. July 2014, 124 (2): 188–95. PMC 4093680 . PMID 24876563. doi:10.1182/blood-2014-05-552729. 
  4. ^ New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management. Critical Care. April 2017, 21 (1): 89. PMC 5391608 . PMID 28407743. doi:10.1186/s13054-017-1678-1. 
  5. ^ Infusion reactions: diagnosis, assessment, and management. Clinical Journal of Oncology Nursing. April 2010, 14 (2): E10–21. PMID 20350882. doi:10.1188/10.CJON.E10-E21. 

本文採用了美國衛生與公眾服務部文件中的公共領域材料: "Common Terminology Criteria for Adverse Events (CTCAE) Version v4.03"