21-脫氧皮質醇

化合物

21-脫氧皮質醇(英語:21-Deoxycortisol,也稱為11β,17α-二羥基孕酮,11β,17α-dihydroxyprogesterone,或11β,17α-二羥基孕-4-烯-3,20-二酮,11β,17α-dihydroxypregn-4-ene-3,20-dione)是一種與皮質醇(11β,17α,21-三羥基孕酮)有關的天然內源甾體物質,可由類固醇11-β-羥化酶英語Steroid 11-beta-hydroxylase(CYP11B1)代謝17α-羥孕酮生成[1]

21-脫氧皮質醇
IUPAC名
(8S,9S,10R,11S,13S,14S,17R)-17-acetyl-11,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
別名 21-Desoxycortisol; 21-Dehydrohydrocortisone; 21-Deoxyhydrocortisone; 11β,17α-Dihydroxyprogesterone; 11β,17α-Dihydroxypregn-4-ene-3,20-dione
識別
CAS號 641-77-0  checkY
PubChem 92827
ChemSpider 83796
SMILES
 
  • CC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)O
ChEBI 28697
KEGG C05497
性質
化學式 C21H30O4
摩爾質量 346.46 g·mol−1
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

參考文獻

  1. ^ Cristoni S, Cuccato D, Sciannamblo M, Bernardi LR, Biunno I, Gerthoux P, Russo G, Weber G, Mora S. Analysis of 21-deoxycortisol, a marker of congenital adrenal hyperplasia, in blood by atmospheric pressure chemical ionization and electrospray ionization using multiple reaction monitoring. Rapid Commun. Mass Spectrom. 2004, 18 (1): 77–82. Bibcode:2004RCMS...18...77C. PMID 14689562. doi:10.1002/rcm.1284. 

外部連結