MALAT-1(英語:metastasis associated lung adenocarcinoma transcript 1的縮寫,也稱為NEAT2noncoding nuclear-enriched abundant transcript 2)是一個長鏈非編碼RNA基因,表達於細胞核,在哺乳動物中高度保守[3]。MALAT-1參與調控細胞核的組織、mRNA的選擇性剪接、DNA的表觀遺傳修飾等細胞中的多種反應,可控制參與腫瘤遠端轉移的基因表現[4]。此RNA表現異常與糖尿病癌症等多種疾病有關[5][6],其高表現和多種癌症較差的存活率呈正相關[7][8]

MALAT1
識別號
別名MALAT1;, HCN, LINC00047, MALAT-1, NCRNA00047, NEAT2, PRO2853, mascRNA, metastasis associated lung adenocarcinoma transcript 1 (non-protein coding), metastasis associated lung adenocarcinoma transcript 1
外部IDOMIM607924 GeneCardsMALAT1
基因位置(人類
11號染色體
染色體11號染色體[1]
11號染色體
MALAT1的基因位置
MALAT1的基因位置
基因座11q13.1起始65,497,688 bp[1]
終止65,506,516 bp[1]
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

無數據

無數據

蛋白序列

無數據

無數據

基因位置​(UCSC)Chr 11: 65.5 – 65.51 Mb無數據
PubMed​查找[2]無數據
維基數據
檢視/編輯人類
MALAT-1的二級結構
預測的MALAT-1的二級結構保守序列
識別符
代號 MALAT1
Rfam RF01871
其他數據
RNA類型 長鏈非編碼RNA;
真核生物;

另見

參考文獻

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000251562 - Ensembl, May 2017
  2. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ Hutchinson JN, Ensminger AW, Clemson CM, Lynch CR, Lawrence JB, Chess A. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains. BMC Genomics. 2007, 8: 39. PMC 1800850 . PMID 17270048. doi:10.1186/1471-2164-8-39. 
  4. ^ Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, Zörnig M, MacLeod AR, Spector DL, Diederichs S. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Research. February 2013, 73 (3): 1180–1189. PMC 3589741 . PMID 23243023. doi:10.1158/0008-5472.CAN-12-2850. 
  5. ^ Wu Y, Huang C, Meng X, Li J. Long Noncoding RNA MALAT1: Insights into its Biogenesis and Implications in Human Disease. Current Pharmaceutical Design. 2015, 21 (34): 5017–5028. PMID 26205289. doi:10.2174/1381612821666150724115625. 
  6. ^ Yoshimoto R, Mayeda A, Yoshida M, Nakagawa S. MALAT1 long non-coding RNA in cancer. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. January 2016, 1859 (1): 192–199. PMID 26434412. doi:10.1016/j.bbagrm.2015.09.012. 
  7. ^ Tian X, Xu G. Clinical value of lncRNA MALAT1 as a prognostic marker in human cancer: systematic review and meta-analysis. BMJ Open. 2015, 5 (9): e008653. PMC 4593150 . PMID 26423854. doi:10.1136/bmjopen-2015-008653.   
  8. ^ Wei Y, Niu B. Role of MALAT1 as a Prognostic Factor for Survival in Various Cancers: A Systematic Review of the Literature with Meta-Analysis. Disease Markers. 2015, 2015: 164635. PMC 4572489 . PMID 26420912. doi:10.1155/2015/164635 . 

外部連結