人臍靜脈內皮細胞

人臍靜脈內皮細胞（Human umbilical vein endothelial cell、HUVEC）是源自臍帶靜脈內皮的細胞系，最早在1970年代進行分離，並且在體外培養^[1] 。它們可以用作研究內皮細胞功能和病理學（例如血管新生）的實驗模型^[2] 。使用它們的原因包括成本低，並且簡單的技術就可將它們與通常在分娩後切除的臍帶分離。 HUVEC細胞很容易就可以在實驗室內增殖。它們像人臍動脈內皮細胞（HUAEC）一樣，當襯砌血管壁時就會表現出鵝卵石狀表型。

HUVEC細胞的角蛋白細胞骨架的顯微圖像

目前已知Anip973培養上清液對HUVEC細胞具有促分裂增殖作用^[3]^[4]，機制可以是培養上清液內含的細胞因子激活了週期蛋白D激酶、導致週期蛋白D（英語：Cyclin D）和週期蛋白依賴性激酶的高度表達，從而誘導更多細胞進入S期，同時增加去氧核糖核酸的合成^[4]。

參考資料

^ Jiménez, N; Krouwer, VJ; Post, JA. A new, rapid and reproducible method to obtain high quality endothelium in vitro.. Cytotechnology. 2013-01, 65 (1): 1–14 [2020-02-20]. PMID 22573289. doi:10.1007/s10616-012-9459-9. （原始內容存檔於2020-02-20）.
^ Park HJ, Zhang Y, Georgescu SP, Johnson KL, Kong D, Galper JB. Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis. Stem Cell Rev. 2006, 2 (2): 93–102. PMID 17237547. doi:10.1007/s12015-006-0015-x.
^ Wang Ji; Zhang Qian; Xie Hua; Gu LiGang; Niu XuYan; Liu LinTao. Effect of Hydroxy Safflor Yellow A on the proliferation of human umbilical vein endothelial cells with the stimulus of tumor cell. China Journal of Traditional Chinese Medicine and Pharmacy. 2009, 24 (5): 572-575 [2020-02-20]. （原始內容存檔於2020-02-20）.
^ ^4.0 ^4.1 Zhang, C; Li, Y; Wang, J; Li, K. [The Supernatant Obtained from Cultured Anip973 Cells Enhances the Biological Activities of HUVEC].. Zhongguo fei ai za zhi = Chinese journal of lung cancer. 2015-11, 18 (11): 668–73 [2020-02-20]. PMID 26582221. doi:10.3779/j.issn.1009-3419.2015.11.02.

外部連結

醫學主題詞表（MeSH）：Human umbilical vein endothelial cells
Understanding the Vasculature with the Help of HUVECs （頁面存檔備份，存於互聯網檔案館）
Primary Umbilical Vein Endothelial Cells (Normal, Human) （頁面存檔備份，存於互聯網檔案館） at ATCC

[1] Jiménez, N; Krouwer, VJ; Post, JA. A new, rapid and reproducible method to obtain high quality endothelium in vitro.. Cytotechnology. 2013-01, 65 (1): 1–14 [2020-02-20]. PMID 22573289. doi:10.1007/s10616-012-9459-9. （原始內容存檔於2020-02-20）.

[pmid17237547-2] Park HJ, Zhang Y, Georgescu SP, Johnson KL, Kong D, Galper JB. Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis. Stem Cell Rev. 2006, 2 (2): 93–102. PMID 17237547. doi:10.1007/s12015-006-0015-x.

[3] Wang Ji; Zhang Qian; Xie Hua; Gu LiGang; Niu XuYan; Liu LinTao. Effect of Hydroxy Safflor Yellow A on the proliferation of human umbilical vein endothelial cells with the stimulus of tumor cell. China Journal of Traditional Chinese Medicine and Pharmacy. 2009, 24 (5): 572-575 [2020-02-20]. （原始內容存檔於2020-02-20）.

[Zhang-4] 4.0 ^4.1 Zhang, C; Li, Y; Wang, J; Li, K. [The Supernatant Obtained from Cultured Anip973 Cells Enhances the Biological Activities of HUVEC].. Zhongguo fei ai za zhi = Chinese journal of lung cancer. 2015-11, 18 (11): 668–73 [2020-02-20]. PMID 26582221. doi:10.3779/j.issn.1009-3419.2015.11.02.

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