頭孢匹胺

化合物

頭孢匹胺也稱為「頭孢吡胺」「頭孢吡四唑」或「甲吡唑頭孢菌素」,是一種第三代頭孢菌素。此抗生素革蘭氏陽性菌(包括葡萄球菌鏈球菌消化球菌等)具有很強的抗菌作用,對綠膿桿菌革蘭氏陰性桿菌也有較強的作用。頭孢匹胺對β-內酰胺酶穩定。

頭孢匹胺
臨床資料
給藥途徑靜脈注射肌肉注射
ATC碼
藥物動力學數據
血漿蛋白結合率93%至99.3%
生物半衰期4.44 hours
排泄途徑Renal and fecal
識別資訊
  • 7-[2-[(4-羥基-6-甲基吡啶-3-羰基)-氨基]-2-(4-羥基苯基)-乙酰氨基]-3-(1-甲基-1H-四唑-5-硫代甲基)-8-氧代-5-硫雜-1-氮雜雙環[4.2.0]辛-2-烯-2-羧酸
    (6R)-7[(2R)-2-(4-hydroxyphenyl)-2-[(6-methyl-
    4-oxo-1H-pyridine-3-carbonyl)amino]acetyl]amino
    3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-
    5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS號70797-11-4  checkY
PubChem CID
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ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C25H24N8O7S2
摩爾質量612.64 g/mol

外部連結

  • Wang H, Yu Y, Xie X, Wang C, Zhang Y, Yuan Y, Zhang X, Liu J, Wang P, Chen M. In-vitro antibacterial activities of cefpiramide and other broad-spectrum antibiotics against 440 clinical isolates in China.. J Infect Chemother. 2000, 6 (2): 81–5. PMID 11810540. doi:10.1007/PL00012156. 
  • Iakovlev V, Vishnevskiĭ V, Khlebnikov E, Khadin I, Plavlova M, Elagina L, Izotova G. [Cefpiramide (Tamicin) in the treatment of purulent complications of abdominal surgery]. Antibiot Khimioter. 1995, 40 (9): 30–4. PMID 8651827. 
  • Sampi K, Hattori M. [Comparative study of cefpiramide + amikacin versus piperacillin + amikacin in granulocytopenic patients: a randomized, prospective study]. Gan To Kagaku Ryoho. 1992, 19 (9): 1315–20. PMID 1503486.