头孢匹胺

化合物

头孢匹胺也称为“头孢吡胺”“头孢吡四唑”或“甲吡唑头孢菌素”,是一种第三代头孢菌素。此抗生素革兰氏阳性菌(包括葡萄球菌链球菌消化球菌等)具有很强的抗菌作用,对绿脓杆菌革兰氏阴性杆菌也有较强的作用。头孢匹胺对β-内酰胺酶稳定。

头孢匹胺
临床资料
给药途径静脉注射肌肉注射
ATC码
药物动力学数据
血浆蛋白结合率93%至99.3%
生物半衰期4.44 hours
排泄途径Renal and fecal
识别信息
  • 7-[2-[(4-羟基-6-甲基吡啶-3-羰基)-氨基]-2-(4-羟基苯基)-乙酰氨基]-3-(1-甲基-1H-四唑-5-硫代甲基)-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸
    (6R)-7[(2R)-2-(4-hydroxyphenyl)-2-[(6-methyl-
    4-oxo-1H-pyridine-3-carbonyl)amino]acetyl]amino
    3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-
    5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS号70797-11-4  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C25H24N8O7S2
摩尔质量612.64 g/mol

外部链接

  • Wang H, Yu Y, Xie X, Wang C, Zhang Y, Yuan Y, Zhang X, Liu J, Wang P, Chen M. In-vitro antibacterial activities of cefpiramide and other broad-spectrum antibiotics against 440 clinical isolates in China.. J Infect Chemother. 2000, 6 (2): 81–5. PMID 11810540. doi:10.1007/PL00012156. 
  • Iakovlev V, Vishnevskiĭ V, Khlebnikov E, Khadin I, Plavlova M, Elagina L, Izotova G. [Cefpiramide (Tamicin) in the treatment of purulent complications of abdominal surgery]. Antibiot Khimioter. 1995, 40 (9): 30–4. PMID 8651827. 
  • Sampi K, Hattori M. [Comparative study of cefpiramide + amikacin versus piperacillin + amikacin in granulocytopenic patients: a randomized, prospective study]. Gan To Kagaku Ryoho. 1992, 19 (9): 1315–20. PMID 1503486.