聚氨丙基雙胍

聚氨丙基雙胍
別名	Polyamine-propyl-biguanidine
識別
縮寫	PAPB
CAS編號	133029-32-0
ChemSpider	none
性質
化學式	(C5H11N5)n
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

聚氨丙基雙胍（英語：Polyaminopropyl biguanide，PAPB）是一種高分子聚合物，其結構單元包含兩個胍基和三個亞甲基，為聚己雙胍的同系物。PAPB具有一些抗菌活性，但抗菌效果遠低於聚己雙胍^[1]。2024年3月，歐盟不再批准聚氨丙基雙胍作為生物活性基材使用^[2]。

名字爭議

在某些領域，特別是化妝品領域，聚氨丙基雙胍（PAPB）容易與聚己雙胍（PHMB）混淆^[3] ^[4]。

參考文獻

^ Rembe, J.-D., Fromm-Dornieden, C., Schafer, N., Böhm, J. K., & Stuermer, E. K. (2016). Comparing two polymeric biguanides: chemical distinction, antiseptic efficacy and cytotoxicity of polyaminopropyl biguanide and polyhexamethylene biguanide. *Journal of Medical Microbiology*, 65(8), 867
^ European Chemicals Agency (ECHA). (n.d.). List of approved active substances. Retrieved May 24, 2024, from https://echa.europa.eu/regulations/biocidal-products-regulation/approval-of-active-substances/list-of-approved-active-substances
^ Cosmetic Ingredient Review Expert Panel. Safety Assessment of Polyaminopropyl Biguanide as Used in Cosmetics (PDF). Cosmetic Ingredient Review (CIR). May 12, 2014 [2024-05-07].
^ Sukakul, Thanisorn; Dahlin, Jakob; Pontén, Ann; Antelmi, Annarita; Bruze, Magnus; Hamnerius, Nils; Hauksson, Inese; Isaksson, Marléne; Lejding, Tina; Svedman, Cecilia. Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide). Contact Dermatitis. 2021, 84 (5): 326–331. PMC 8048451  . PMID 33098110. doi:10.1111/cod.13728.

[1] Rembe, J.-D., Fromm-Dornieden, C., Schafer, N., Böhm, J. K., & Stuermer, E. K. (2016). Comparing two polymeric biguanides: chemical distinction, antiseptic efficacy and cytotoxicity of polyaminopropyl biguanide and polyhexamethylene biguanide. *Journal of Medical Microbiology*, 65(8), 867

[2] European Chemicals Agency (ECHA). (n.d.). List of approved active substances. Retrieved May 24, 2024, from https://echa.europa.eu/regulations/biocidal-products-regulation/approval-of-active-substances/list-of-approved-active-substances

[3] Cosmetic Ingredient Review Expert Panel. Safety Assessment of Polyaminopropyl Biguanide as Used in Cosmetics (PDF). Cosmetic Ingredient Review (CIR). May 12, 2014 [2024-05-07].

[4] Sukakul, Thanisorn; Dahlin, Jakob; Pontén, Ann; Antelmi, Annarita; Bruze, Magnus; Hamnerius, Nils; Hauksson, Inese; Isaksson, Marléne; Lejding, Tina; Svedman, Cecilia. Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide). Contact Dermatitis. 2021, 84 (5): 326–331. PMC 8048451  . PMID 33098110. doi:10.1111/cod.13728.

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