聚氨丙基双胍

聚氨丙基双胍
别名	Polyamine-propyl-biguanidine
识别
缩写	PAPB
CAS号	133029-32-0
ChemSpider	none
性质
化学式	(C5H11N5)n
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

聚氨丙基双胍（英語：Polyaminopropyl biguanide，PAPB）是一种高分子聚合物，其结构单元包含两个胍基和三个亚甲基，为聚己双胍的同系物。PAPB具有一些抗菌活性，但抗菌效果远低于聚己双胍^[1]。2024年3月，欧盟不再批准聚氨丙基双胍作为生物活性基材使用^[2]。

名字争议

在某些领域，特别是化妆品领域，聚氨丙基双胍（PAPB）容易与聚己双胍（PHMB）混淆^[3] ^[4]。

参考文献

^ Rembe, J.-D., Fromm-Dornieden, C., Schafer, N., Böhm, J. K., & Stuermer, E. K. (2016). Comparing two polymeric biguanides: chemical distinction, antiseptic efficacy and cytotoxicity of polyaminopropyl biguanide and polyhexamethylene biguanide. *Journal of Medical Microbiology*, 65(8), 867
^ European Chemicals Agency (ECHA). (n.d.). List of approved active substances. Retrieved May 24, 2024, from https://echa.europa.eu/regulations/biocidal-products-regulation/approval-of-active-substances/list-of-approved-active-substances
^ Cosmetic Ingredient Review Expert Panel. Safety Assessment of Polyaminopropyl Biguanide as Used in Cosmetics (PDF). Cosmetic Ingredient Review (CIR). May 12, 2014 [2024-05-07].
^ Sukakul, Thanisorn; Dahlin, Jakob; Pontén, Ann; Antelmi, Annarita; Bruze, Magnus; Hamnerius, Nils; Hauksson, Inese; Isaksson, Marléne; Lejding, Tina; Svedman, Cecilia. Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide). Contact Dermatitis. 2021, 84 (5): 326–331. PMC 8048451  . PMID 33098110. doi:10.1111/cod.13728.

[1] Rembe, J.-D., Fromm-Dornieden, C., Schafer, N., Böhm, J. K., & Stuermer, E. K. (2016). Comparing two polymeric biguanides: chemical distinction, antiseptic efficacy and cytotoxicity of polyaminopropyl biguanide and polyhexamethylene biguanide. *Journal of Medical Microbiology*, 65(8), 867

[2] European Chemicals Agency (ECHA). (n.d.). List of approved active substances. Retrieved May 24, 2024, from https://echa.europa.eu/regulations/biocidal-products-regulation/approval-of-active-substances/list-of-approved-active-substances

[3] Cosmetic Ingredient Review Expert Panel. Safety Assessment of Polyaminopropyl Biguanide as Used in Cosmetics (PDF). Cosmetic Ingredient Review (CIR). May 12, 2014 [2024-05-07].

[4] Sukakul, Thanisorn; Dahlin, Jakob; Pontén, Ann; Antelmi, Annarita; Bruze, Magnus; Hamnerius, Nils; Hauksson, Inese; Isaksson, Marléne; Lejding, Tina; Svedman, Cecilia. Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide). Contact Dermatitis. 2021, 84 (5): 326–331. PMC 8048451  . PMID 33098110. doi:10.1111/cod.13728.

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