過氧化物酶體增殖物活化受體γ

位於3號人類染色體的基因

過氧化物酶體增殖物活化受體γPeroxisome proliferator-activated receptor gamma ,縮寫為PPAR-γPPARG),也稱胰島素增敏劑受體(glitazone receptor),或 NR1C3(意為核受體第一亞科C集團第3號,nuclear receptor subfamily 1, group C, member 3)是一種位於人類染色體上的二型核受體,由PPARG基因編碼。[2][3][4]脂肪細胞胰島素有重要的作用,是治療糖尿病的研究對象之一。[5]

過氧化物酶體增殖物活化受體γ
PPAR-G dimer bound to DNA. PDB rendering based on 3e00[1].
有效結構
PDB 直系同源檢索:PDBe, RCSB
標識
代號 PPARG; CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARgamma
擴展標識 遺傳學601487 鼠基因97747 同源基因7899 IUPHAR:   ChEMBL: 235 GeneCards: PPARG Gene
RNA表達模式
更多表達數據
直系同源體
物種 人類 小鼠
Entrez 5468 19016
Ensembl ENSG00000132170 ENSMUSG00000000440
UniProt P37231 P37238
mRNA序列 NM_005037 NM_001127330
蛋白序列 NP_005028 NP_001120802
基因位置 Chr 3:
12.33 – 12.48 Mb
Chr 6:
115.36 – 115.49 Mb
PubMed查詢 [1] [2]

來源

  1. ^ Vikas Chandra, Pengxiang Huang, Yoshitomo Hamuro, Srilatha Raghuram, Yongjun Wang, Thomas P. Burris, Fraydoon Rastinejad. Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature. 2008-11-20, 456 (7220): 350–356 [2019-05-26]. ISSN 1476-4687. PMC 2743566 . PMID 19043829. doi:10.1038/nature07413. 
  2. ^ Greene ME, Blumberg B, McBride OW, Yi HF, Kronquist K, Kwan K, Hsieh L, Greene G, Nimer SD. Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expr. 1995, 4 (4-5): 281–99. PMID 7787419. 
  3. ^ Elbrecht A, Chen Y, Cullinan CA, Hayes N, Leibowitz M, Moller DE, Berger J. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2. Biochem. Biophys. Res. Commun. July 1996, 224 (2): 431–7. PMID 8702406. doi:10.1006/bbrc.1996.1044. 
  4. ^ Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol. Rev. December 2006, 58 (4): 726–41. PMID 17132851. doi:10.1124/pr.58.4.5. 
  5. ^ 劉英姿 ,劉昭前 , 周宏灝. 过氧化物酶体增殖物激活受体γ激动剂和拮抗剂研究进展 (PDF). 中國臨床藥理學雜誌. 2007, 23 (4): 308–310. 1001-6821(2007)04-0308-03 (中文). [永久失效連結]