过氧化物酶体增殖物活化受体γ

位於3號人類染色體的基因

过氧化物酶体增殖物活化受体γPeroxisome proliferator-activated receptor gamma ,缩写为PPAR-γPPARG),也称胰岛素增敏剂受体(glitazone receptor),或 NR1C3(意为核受体第一亚科C集团第3号,nuclear receptor subfamily 1, group C, member 3)是一种位于人类染色体上的二型核受体,由PPARG基因编码。[2][3][4]脂肪细胞胰岛素有重要的作用,是治疗糖尿病的研究对象之一。[5]

过氧化物酶体增殖物活化受体γ
PPAR-G dimer bound to DNA. PDB rendering based on 3e00[1].
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 PPARG; CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARgamma
扩展标识 遗传学601487 鼠基因97747 同源基因7899 IUPHAR:   ChEMBL: 235 GeneCards: PPARG Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 5468 19016
Ensembl ENSG00000132170 ENSMUSG00000000440
UniProt P37231 P37238
mRNA序列 NM_005037 NM_001127330
蛋白序列 NP_005028 NP_001120802
基因位置 Chr 3:
12.33 – 12.48 Mb
Chr 6:
115.36 – 115.49 Mb
PubMed查询 [1] [2]

来源

  1. ^ Vikas Chandra, Pengxiang Huang, Yoshitomo Hamuro, Srilatha Raghuram, Yongjun Wang, Thomas P. Burris, Fraydoon Rastinejad. Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature. 2008-11-20, 456 (7220): 350–356 [2019-05-26]. ISSN 1476-4687. PMC 2743566 . PMID 19043829. doi:10.1038/nature07413. 
  2. ^ Greene ME, Blumberg B, McBride OW, Yi HF, Kronquist K, Kwan K, Hsieh L, Greene G, Nimer SD. Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expr. 1995, 4 (4-5): 281–99. PMID 7787419. 
  3. ^ Elbrecht A, Chen Y, Cullinan CA, Hayes N, Leibowitz M, Moller DE, Berger J. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2. Biochem. Biophys. Res. Commun. July 1996, 224 (2): 431–7. PMID 8702406. doi:10.1006/bbrc.1996.1044. 
  4. ^ Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol. Rev. December 2006, 58 (4): 726–41. PMID 17132851. doi:10.1124/pr.58.4.5. 
  5. ^ 刘英姿 ,刘昭前 , 周宏灏. 过氧化物酶体增殖物激活受体γ激动剂和拮抗剂研究进展 (PDF). 中国临床药理学杂志. 2007, 23 (4): 308–310. 1001-6821(2007)04-0308-03 (中文). [永久失效链接]