洛美曲林

化合物

洛美曲林国际非专有药名Lometraline,研发代号:CP-14,368)是一种含氮有机氯化合物,化学式C13H18ClNO,属于1-氨基四氢化萘衍生物,能用作选择性5-羟色胺再摄取抑制剂[1],最初由辉瑞公司申请专利[2][3]

洛美曲林
临床资料
其他名称N,N-dimethyl-8-chloro-5-methoxy-1-aminotetralin
ATC码
  • 未分配
识别信息
  • 8-chloro-5-methoxy-N,N-dimethyl-1,2,3,4-tetrahydro-1-naphthalenamine
CAS号39951-65-0
34552-78-8 (hydrochloride))
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C13H18ClNO
摩尔质量239.74 g·mol−1
3D模型(JSmol英语JSmol
  • Clc1ccc(OC)c2c1C(N(C)C)CCC2
  • InChI=1S/C13H18ClNO/c1-15(2)11-6-4-5-9-12(16-3)8-7-10(14)13(9)11/h7-8,11H,4-6H2,1-3H3
  • Key:MTWNWMGGMZUIMZ-UHFFFAOYSA-N

参考文献

  1. ^ Park S, Gershon S, Angrist B, Floyd A. Evaluation of an aminotetraline, CP 14.368, as an antidepressant. Current Therapeutic Research, Clinical and Experimental. February 1972, 14 (2): 65–70. PMID 4401233. 
  2. ^ Drake E. Saunders pharmaceutical word book, 1994. W.B. Saunders Co. 27 January 1994 [27 April 2012]. ISBN 978-0-7216-5254-2. 
  3. ^ United States. Patent Office. Lometraline: tranquillizer, anti-parkinson agent. Official gazette of the United States Patent Office: Patents. The Office. 1972 [27 April 2012].