洛美曲林

化合物

洛美曲林國際非專有藥名Lometraline,研發代號:CP-14,368)是一種含氮有機氯化合物,化學式C13H18ClNO,屬於1-氨基四氫化萘衍生物,能用作選擇性5-羥色胺再攝取抑制劑[1],最初由輝瑞公司申請專利[2][3]

洛美曲林
臨床資料
其他名稱N,N-dimethyl-8-chloro-5-methoxy-1-aminotetralin
ATC碼
  • 未分配
識別資訊
  • 8-chloro-5-methoxy-N,N-dimethyl-1,2,3,4-tetrahydro-1-naphthalenamine
CAS號39951-65-0
34552-78-8 (hydrochloride))
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C13H18ClNO
摩爾質量239.74 g·mol−1
3D模型(JSmol英語JSmol
  • Clc1ccc(OC)c2c1C(N(C)C)CCC2
  • InChI=1S/C13H18ClNO/c1-15(2)11-6-4-5-9-12(16-3)8-7-10(14)13(9)11/h7-8,11H,4-6H2,1-3H3
  • Key:MTWNWMGGMZUIMZ-UHFFFAOYSA-N

參考文獻

  1. ^ Park S, Gershon S, Angrist B, Floyd A. Evaluation of an aminotetraline, CP 14.368, as an antidepressant. Current Therapeutic Research, Clinical and Experimental. February 1972, 14 (2): 65–70. PMID 4401233. 
  2. ^ Drake E. Saunders pharmaceutical word book, 1994. W.B. Saunders Co. 27 January 1994 [27 April 2012]. ISBN 978-0-7216-5254-2. 
  3. ^ United States. Patent Office. Lometraline: tranquillizer, anti-parkinson agent. Official gazette of the United States Patent Office: Patents. The Office. 1972 [27 April 2012].