MC3T3

MC3T3是源自小鼠颅顶的成骨细胞前体细胞系^[1]。目前已经分离出MC3T3细胞的许多衍生物，以选择不同程度的成骨潜力，并且已被广泛用作研究骨生物学的模型系统。有教科书将其子系MC3T3-E1细胞，称为研究着颅骨成骨细胞转录控制的最方便系统之一^[2]。这是一种自发转化的及永生化的细胞系，故而是非常方便的研究工具，但是在将这些结论外推到正常细胞或正常人类细胞时，应该要谨慎判断^[3]^[4] 。

另见

MC3T3-E1细胞

参考资料

^ Kodama, Hiro-aki; Amagai, Yuji; Sudo, Hiroko; Kasai, Shiro; Yamamoto, Shigehisa. Establishment of a clonal osteogenic cell line from newborn mouse calvaria. Japanese Journal of Oral Biology. 1981, 23 (4): 899–901. doi:10.2330/joralbiosci1965.23.899.
^ John P. Bilezikian; Lawrence G. Raisz; Gideon A. Rodan. Principles of Bone Biology. Academic Press. 19 January 2002. ISBN 978-0-08-053960-7.
^ Arriero, María del Mar; Ramis, Joana M.; Perelló, Joan; Monjo, Marta. Differential Response of MC3T3-E1 and Human Mesenchymal Stem Cells to Inositol Hexakisphosphate. Cellular Physiology and Biochemistry. 2012, 30 (4): 974–986. ISSN 1421-9778. doi:10.1159/000341474 （英语）.
^ Fernandes, Hugo; Dechering, Koen; van Someren, Eugene; Steeghs, Ilse; Apotheker, Marion; Mentink, Anouk; van Blitterswijk, Clemens; de Boer, Jan. Effect of Chordin-Like 1 on MC3T3-E1 and Human Mesenchymal Stem Cells. Cells Tissues Organs. 2010, 191 (6): 443–452. ISSN 1422-6405. doi:10.1159/000281825 （英语）.

外部链接

Cellosaurus entry for MC3T3 （页面存档备份，存于互联网档案馆）
Cellosaurus entry for MC3T3-E1 （页面存档备份，存于互联网档案馆）

这是一篇分子与细胞生物学（分子细胞生物学）小作品。您可以通过编辑或修订扩充其内容。

[1] Kodama, Hiro-aki; Amagai, Yuji; Sudo, Hiroko; Kasai, Shiro; Yamamoto, Shigehisa. Establishment of a clonal osteogenic cell line from newborn mouse calvaria. Japanese Journal of Oral Biology. 1981, 23 (4): 899–901. doi:10.2330/joralbiosci1965.23.899.

[BilezikianRaisz2002-2] John P. Bilezikian; Lawrence G. Raisz; Gideon A. Rodan. Principles of Bone Biology. Academic Press. 19 January 2002. ISBN 978-0-08-053960-7.

[3] Arriero, María del Mar; Ramis, Joana M.; Perelló, Joan; Monjo, Marta. Differential Response of MC3T3-E1 and Human Mesenchymal Stem Cells to Inositol Hexakisphosphate. Cellular Physiology and Biochemistry. 2012, 30 (4): 974–986. ISSN 1421-9778. doi:10.1159/000341474 （英语）.

[4] Fernandes, Hugo; Dechering, Koen; van Someren, Eugene; Steeghs, Ilse; Apotheker, Marion; Mentink, Anouk; van Blitterswijk, Clemens; de Boer, Jan. Effect of Chordin-Like 1 on MC3T3-E1 and Human Mesenchymal Stem Cells. Cells Tissues Organs. 2010, 191 (6): 443–452. ISSN 1422-6405. doi:10.1159/000281825 （英语）.

[1]

[2]

[3]

[4]